GET https://rct.dev.bbntimes.com/science/probiotic-pros-and-cons

Response
200 OK
IP
18.188.220.221
Profiled on
Token
2071b0

ArticleController :: show

Request

GET Parameters

None

POST Parameters

None

Uploaded Files

None

Request Attributes

Key Value
_controller 
"App\Controller\ArticleController::show"
_firewall_context 
"security.firewall.map.context.main"
_links 
Symfony\Component\WebLink\GenericLinkProvider {#3615
  -links: [
    3736 => Symfony\Component\WebLink\Link {#3736
      -href: "/build/runtime.js"
      -rel: [
        "preload" => "preload"
      ]
      -attributes: [
        "as" => "script"
      ]
    }
    3734 => Symfony\Component\WebLink\Link {#3734
      -href: "/build/644.js"
      -rel: [
        "preload" => "preload"
      ]
      -attributes: [
        "as" => "script"
      ]
    }
    3733 => Symfony\Component\WebLink\Link {#3733
      -href: "/build/502.js"
      -rel: [
        "preload" => "preload"
      ]
      -attributes: [
        "as" => "script"
      ]
    }
    3732 => Symfony\Component\WebLink\Link {#3732
      -href: "/build/app.js"
      -rel: [
        "preload" => "preload"
      ]
      -attributes: [
        "as" => "script"
      ]
    }
    3731 => Symfony\Component\WebLink\Link {#3731
      -href: "/build/view-more.js"
      -rel: [
        "preload" => "preload"
      ]
      -attributes: [
        "as" => "script"
      ]
    }
    3730 => Symfony\Component\WebLink\Link {#3730
      -href: "/build/term-condition.js"
      -rel: [
        "preload" => "preload"
      ]
      -attributes: [
        "as" => "script"
      ]
    }
    3729 => Symfony\Component\WebLink\Link {#3729
      -href: "/build/contact.js"
      -rel: [
        "preload" => "preload"
      ]
      -attributes: [
        "as" => "script"
      ]
    }
    3728 => Symfony\Component\WebLink\Link {#3728
      -href: "/build/scroll-infinite-article.js"
      -rel: [
        "preload" => "preload"
      ]
      -attributes: [
        "as" => "script"
      ]
    }
    3727 => Symfony\Component\WebLink\Link {#3727
      -href: "/build/app.css"
      -rel: [
        "preload" => "preload"
      ]
      -attributes: [
        "as" => "style"
      ]
    }
    3726 => Symfony\Component\WebLink\Link {#3726
      -href: "/build/cookie-style.css"
      -rel: [
        "preload" => "preload"
      ]
      -attributes: [
        "as" => "style"
      ]
    }
    3725 => Symfony\Component\WebLink\Link {#3725
      -href: "/build/term-condition-css.css"
      -rel: [
        "preload" => "preload"
      ]
      -attributes: [
        "as" => "style"
      ]
    }
    3724 => Symfony\Component\WebLink\Link {#3724
      -href: "/build/contact-css.css"
      -rel: [
        "preload" => "preload"
      ]
      -attributes: [
        "as" => "style"
      ]
    }
    3723 => Symfony\Component\WebLink\Link {#3723
      -href: "/build/comment-css.css"
      -rel: [
        "preload" => "preload"
      ]
      -attributes: [
        "as" => "style"
      ]
    }
  ]
}
_route 
"article_show"
_route_params 
[
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  "slug" => "probiotic-pros-and-cons"
]
_security_firewall_run 
"_security_main"
_stopwatch_token 
"2c377f"
category 
"science"
slug 
"probiotic-pros-and-cons"

Request Headers

Header Value
accept 
"*/*"
accept-encoding 
"gzip, br, zstd, deflate"
connection 
"close"
cookie 
"PHPSESSID=e9fghe0pugq2ped5hqrd1ar649"
host 
"rct.dev.bbntimes.com"
user-agent 
"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)"
x-php-ob-level 
"1"

Request Content

Request content not available (it was retrieved as a resource).

Response

Response Headers

Header Value
cache-control 
"no-cache, private"
content-type 
"text/html; charset=UTF-8"
date 
"Sat, 22 Feb 2025 08:35:56 GMT"
link 
"</build/runtime.js>; rel="preload"; as="script",</build/644.js>; rel="preload"; as="script",</build/502.js>; rel="preload"; as="script",</build/app.js>; rel="preload"; as="script",</build/view-more.js>; rel="preload"; as="script",</build/term-condition.js>; rel="preload"; as="script",</build/contact.js>; rel="preload"; as="script",</build/scroll-infinite-article.js>; rel="preload"; as="script",</build/app.css>; rel="preload"; as="style",</build/cookie-style.css>; rel="preload"; as="style",</build/term-condition-css.css>; rel="preload"; as="style",</build/contact-css.css>; rel="preload"; as="style",</build/comment-css.css>; rel="preload"; as="style""
x-debug-token 
"2071b0"

Cookies

Request Cookies

Key Value
PHPSESSID 
"e9fghe0pugq2ped5hqrd1ar649"

Response Cookies

No response cookies

Session 6

Session Metadata

Key Value
Created 
"Sat, 22 Feb 25 08:35:54 +0000"
Last used 
"Sat, 22 Feb 25 08:35:54 +0000"
Lifetime 
0

Session Attributes

Attribute Value
_csrf/https-comment 
"5NpDaeXz0ELSxgnWh5zUA1KiKi9tbp6Zr8UZj9iJhbs"
_csrf/https-cookie_accept 
"_fEDaa-yvwiHH7oJ95WzpdMhcTKv-20tGtvT6hEFqbQ"

Session Usage

6 Usages
Stateless check enabled
Usage
Symfony\Component\Security\Csrf\TokenStorage\SessionTokenStorage:76
Show trace 
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Symfony\Component\Security\Csrf\TokenStorage\SessionTokenStorage:79
Show trace 
[
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/security-csrf/TokenStorage/SessionTokenStorage.php"
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Symfony\Component\Security\Csrf\TokenStorage\SessionTokenStorage:52
Show trace 
[
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/security-csrf/TokenStorage/SessionTokenStorage.php"
    "line" => 52
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Symfony\Component\Security\Csrf\TokenStorage\SessionTokenStorage:56
Show trace 
[
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    "type" => "->"
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    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpKernel.php"
    "line" => 76
    "function" => "handleRaw"
    "class" => "Symfony\Component\HttpKernel\HttpKernel"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/Kernel.php"
    "line" => 197
    "function" => "handle"
    "class" => "Symfony\Component\HttpKernel\HttpKernel"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/runtime/Runner/Symfony/HttpKernelRunner.php"
    "line" => 35
    "function" => "handle"
    "class" => "Symfony\Component\HttpKernel\Kernel"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/autoload_runtime.php"
    "line" => 29
    "function" => "run"
    "class" => "Symfony\Component\Runtime\Runner\Symfony\HttpKernelRunner"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/public/index.php"
    "line" => 5
    "args" => [
      "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/autoload_runtime.php"
    ]
    "function" => "require_once"
  ]
]
Symfony\Component\Security\Core\Authentication\Token\Storage\UsageTrackingTokenStorage:41
Show trace 
[
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/security-core/Authentication/Token/Storage/UsageTrackingTokenStorage.php"
    "line" => 41
    "function" => "getMetadataBag"
    "class" => "Symfony\Component\HttpFoundation\Session\Session"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/twig-bridge/AppVariable.php"
    "line" => 103
    "function" => "getToken"
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    "type" => "->"
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    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/Extension/CoreExtension.php"
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    "function" => "twig_get_attribute"
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    "class" => "__TwigTemplate_824a013e4f3f4a68e03a2d244e765025"
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    "function" => "displayWithErrorHandling"
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    "line" => 379
    "function" => "display"
    "class" => "Twig\Template"
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  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/TemplateWrapper.php"
    "line" => 38
    "function" => "render"
    "class" => "Twig\Template"
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  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/Environment.php"
    "line" => 280
    "function" => "render"
    "class" => "Twig\TemplateWrapper"
    "type" => "->"
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  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/framework-bundle/Controller/AbstractController.php"
    "line" => 448
    "function" => "render"
    "class" => "Twig\Environment"
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  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/framework-bundle/Controller/AbstractController.php"
    "line" => 453
    "function" => "doRenderView"
    "class" => "Symfony\Bundle\FrameworkBundle\Controller\AbstractController"
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  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/framework-bundle/Controller/AbstractController.php"
    "line" => 253
    "function" => "doRender"
    "class" => "Symfony\Bundle\FrameworkBundle\Controller\AbstractController"
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  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/src/Controller/AppController.php"
    "line" => 126
    "function" => "render"
    "class" => "Symfony\Bundle\FrameworkBundle\Controller\AbstractController"
    "type" => "->"
  ]
  [
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    "line" => 181
    "function" => "renderHeader"
    "class" => "App\Controller\AppController"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpKernel.php"
    "line" => 76
    "function" => "handleRaw"
    "class" => "Symfony\Component\HttpKernel\HttpKernel"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpCache/SubRequestHandler.php"
    "line" => 86
    "function" => "handle"
    "class" => "Symfony\Component\HttpKernel\HttpKernel"
    "type" => "->"
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  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/Fragment/InlineFragmentRenderer.php"
    "line" => 78
    "function" => "handle"
    "class" => "Symfony\Component\HttpKernel\HttpCache\SubRequestHandler"
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  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/Fragment/FragmentHandler.php"
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    "function" => "render"
    "class" => "Symfony\Component\HttpKernel\Fragment\InlineFragmentRenderer"
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    "function" => "render"
    "class" => "Symfony\Component\HttpKernel\Fragment\FragmentHandler"
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  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/twig-bridge/Extension/HttpKernelRuntime.php"
    "line" => 44
    "function" => "render"
    "class" => "Symfony\Component\HttpKernel\DependencyInjection\LazyLoadingFragmentHandler"
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  [
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    "function" => "renderFragment"
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  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/Template.php"
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    "function" => "block_header"
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  [
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    "function" => "displayBlock"
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    "function" => "displayWithErrorHandling"
    "class" => "Twig\Template"
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  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/var/cache/dev/twig/c3/c336f4e76fc20e4db84e3be131276b68.php"
    "line" => 52
    "function" => "display"
    "class" => "Twig\Template"
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  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/Template.php"
    "line" => 394
    "function" => "doDisplay"
    "class" => "__TwigTemplate_3ce0324a396de697d1fad9fabd68df72"
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  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/Template.php"
    "line" => 367
    "function" => "displayWithErrorHandling"
    "class" => "Twig\Template"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/Template.php"
    "line" => 379
    "function" => "display"
    "class" => "Twig\Template"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/TemplateWrapper.php"
    "line" => 38
    "function" => "render"
    "class" => "Twig\Template"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/Environment.php"
    "line" => 280
    "function" => "render"
    "class" => "Twig\TemplateWrapper"
    "type" => "->"
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  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/framework-bundle/Controller/AbstractController.php"
    "line" => 448
    "function" => "render"
    "class" => "Twig\Environment"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/framework-bundle/Controller/AbstractController.php"
    "line" => 453
    "function" => "doRenderView"
    "class" => "Symfony\Bundle\FrameworkBundle\Controller\AbstractController"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/framework-bundle/Controller/AbstractController.php"
    "line" => 253
    "function" => "doRender"
    "class" => "Symfony\Bundle\FrameworkBundle\Controller\AbstractController"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/src/Controller/ArticleController.php"
    "line" => 277
    "function" => "render"
    "class" => "Symfony\Bundle\FrameworkBundle\Controller\AbstractController"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpKernel.php"
    "line" => 181
    "function" => "show"
    "class" => "App\Controller\ArticleController"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpKernel.php"
    "line" => 76
    "function" => "handleRaw"
    "class" => "Symfony\Component\HttpKernel\HttpKernel"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/Kernel.php"
    "line" => 197
    "function" => "handle"
    "class" => "Symfony\Component\HttpKernel\HttpKernel"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/runtime/Runner/Symfony/HttpKernelRunner.php"
    "line" => 35
    "function" => "handle"
    "class" => "Symfony\Component\HttpKernel\Kernel"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/autoload_runtime.php"
    "line" => 29
    "function" => "run"
    "class" => "Symfony\Component\Runtime\Runner\Symfony\HttpKernelRunner"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/public/index.php"
    "line" => 5
    "args" => [
      "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/autoload_runtime.php"
    ]
    "function" => "require_once"
  ]
]
Symfony\Component\Security\Http\Firewall\ContextListener:171
Show trace 
[
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/security-http/Firewall/ContextListener.php"
    "line" => 171
    "function" => "remove"
    "class" => "Symfony\Component\HttpFoundation\Session\Session"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/event-dispatcher/Debug/WrappedListener.php"
    "line" => 116
    "function" => "onKernelResponse"
    "class" => "Symfony\Component\Security\Http\Firewall\ContextListener"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/event-dispatcher/EventDispatcher.php"
    "line" => 220
    "function" => "__invoke"
    "class" => "Symfony\Component\EventDispatcher\Debug\WrappedListener"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/event-dispatcher/EventDispatcher.php"
    "line" => 56
    "function" => "callListeners"
    "class" => "Symfony\Component\EventDispatcher\EventDispatcher"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/event-dispatcher/Debug/TraceableEventDispatcher.php"
    "line" => 139
    "function" => "dispatch"
    "class" => "Symfony\Component\EventDispatcher\EventDispatcher"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpKernel.php"
    "line" => 214
    "function" => "dispatch"
    "class" => "Symfony\Component\EventDispatcher\Debug\TraceableEventDispatcher"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpKernel.php"
    "line" => 202
    "function" => "filterResponse"
    "class" => "Symfony\Component\HttpKernel\HttpKernel"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpKernel.php"
    "line" => 76
    "function" => "handleRaw"
    "class" => "Symfony\Component\HttpKernel\HttpKernel"
    "type" => "->"
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  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/Kernel.php"
    "line" => 197
    "function" => "handle"
    "class" => "Symfony\Component\HttpKernel\HttpKernel"
    "type" => "->"
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  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/runtime/Runner/Symfony/HttpKernelRunner.php"
    "line" => 35
    "function" => "handle"
    "class" => "Symfony\Component\HttpKernel\Kernel"
    "type" => "->"
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  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/autoload_runtime.php"
    "line" => 29
    "function" => "run"
    "class" => "Symfony\Component\Runtime\Runner\Symfony\HttpKernelRunner"
    "type" => "->"
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  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/public/index.php"
    "line" => 5
    "args" => [
      "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/autoload_runtime.php"
    ]
    "function" => "require_once"
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]

Flashes

Flashes

No flash messages were created.

Server Parameters

Server Parameters

Defined in .env

Key Value
APP_ENV 
"dev"
APP_SECRET 
"0a988e63f011514eaabfc650b599af4d"
CORS_ALLOW_ORIGIN 
"*"
DATABASE_URL 
"mysql://bbndb_rctuser:33F5W25z40or0f7@localhost:3306/rct_bbntimes"
GOOGLE_RECAPTCHA_SECRET_KEY 
"6LdV5fgpAAAAANxzTG8ZMfIjil1wu-1vrQvnUt-x"
GOOGLE_RECAPTCHA_SITE_KEY 
"6LdV5fgpAAAAAENKcn73MJAhQrbtQeqgyC4wDLMP"
MAILER_DSN 
"smtp://no-reply%40rct.dev.bbntimes.com:Bl6%26gLD48%26Of919@rct.dev.bbntimes.com:465"
MARIADB_PASSWORD 
"i!87pK&!85ezc8"

Defined as regular env variables

Key Value
APP_DEBUG 
"1"
BASE 
"/public"
CONTEXT_DOCUMENT_ROOT 
"/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com"
CONTEXT_PREFIX 
""
DOCUMENT_ROOT 
"/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com"
FCGI_ROLE 
"RESPONDER"
GATEWAY_INTERFACE 
"CGI/1.1"
HTTPS 
"on"
HTTP_ACCEPT 
"*/*"
HTTP_ACCEPT_ENCODING 
"gzip, br, zstd, deflate"
HTTP_CONNECTION 
"close"
HTTP_COOKIE 
"PHPSESSID=e9fghe0pugq2ped5hqrd1ar649"
HTTP_HOST 
"rct.dev.bbntimes.com"
HTTP_USER_AGENT 
"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)"
PASSENGER_COMPILE_NATIVE_SUPPORT_BINARY 
"0"
PASSENGER_DOWNLOAD_NATIVE_SUPPORT_BINARY 
"0"
PATH 
"/usr/local/sbin:/usr/local/bin:/usr/sbin:/usr/bin:/sbin:/bin:/snap/bin"
PHP_SELF 
"/public/index.php"
PP_CUSTOM_PHP_CGI_INDEX 
"plesk-php81-fastcgi"
PP_CUSTOM_PHP_INI 
"/var/www/vhosts/system/rct.dev.bbntimes.com/etc/php.ini"
QUERY_STRING 
""
REDIRECT_BASE 
"/public"
REDIRECT_HTTPS 
"on"
REDIRECT_PASSENGER_COMPILE_NATIVE_SUPPORT_BINARY 
"0"
REDIRECT_PASSENGER_DOWNLOAD_NATIVE_SUPPORT_BINARY 
"0"
REDIRECT_REDIRECT_HTTPS 
"on"
REDIRECT_REDIRECT_PASSENGER_COMPILE_NATIVE_SUPPORT_BINARY 
"0"
REDIRECT_REDIRECT_PASSENGER_DOWNLOAD_NATIVE_SUPPORT_BINARY 
"0"
REDIRECT_REDIRECT_SCRIPT_URI 
"https://rct.dev.bbntimes.com/science/probiotic-pros-and-cons"
REDIRECT_REDIRECT_SCRIPT_URL 
"/science/probiotic-pros-and-cons"
REDIRECT_REDIRECT_SSL_TLS_SNI 
"rct.dev.bbntimes.com"
REDIRECT_REDIRECT_STATUS 
"200"
REDIRECT_REDIRECT_UNIQUE_ID 
"Z7mMa5DyWLT8YV1VjBo4kgAAAIc"
REDIRECT_SCRIPT_URI 
"https://rct.dev.bbntimes.com/science/probiotic-pros-and-cons"
REDIRECT_SCRIPT_URL 
"/science/probiotic-pros-and-cons"
REDIRECT_SSL_TLS_SNI 
"rct.dev.bbntimes.com"
REDIRECT_STATUS 
"200"
REDIRECT_UNIQUE_ID 
"Z7mMa5DyWLT8YV1VjBo4kgAAAIc"
REDIRECT_URL 
"/public/science/probiotic-pros-and-cons"
REMOTE_ADDR 
"18.188.220.221"
REMOTE_PORT 
"2749"
REQUEST_METHOD 
"GET"
REQUEST_SCHEME 
"https"
REQUEST_TIME 
1740213355
REQUEST_TIME_FLOAT 
1740213355.8736
REQUEST_URI 
"/science/probiotic-pros-and-cons"
SCRIPT_FILENAME 
"/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/public/index.php"
SCRIPT_NAME 
"/public/index.php"
SCRIPT_URI 
"https://rct.dev.bbntimes.com/science/probiotic-pros-and-cons"
SCRIPT_URL 
"/science/probiotic-pros-and-cons"
SERVER_ADDR 
"5.196.1.209"
SERVER_ADMIN 
"[no address given]"
SERVER_NAME 
"rct.dev.bbntimes.com"
SERVER_PORT 
"443"
SERVER_PROTOCOL 
"HTTP/1.1"
SERVER_SIGNATURE 
"<address>Apache Server at rct.dev.bbntimes.com Port 443</address>\n"
SERVER_SOFTWARE 
"Apache"
SSL_TLS_SNI 
"rct.dev.bbntimes.com"
SYMFONY_DOTENV_VARS 
"APP_ENV,APP_SECRET,DATABASE_URL,MARIADB_PASSWORD,CORS_ALLOW_ORIGIN,MAILER_DSN,GOOGLE_RECAPTCHA_SECRET_KEY,GOOGLE_RECAPTCHA_SITE_KEY"
UNIQUE_ID 
"Z7mMa5DyWLT8YV1VjBo4kgAAAIc"

Sub Requests 6

CookieController :: renderAnalysis (token = f31211)

Key Value
_controller 
"App\Controller\CookieController::renderAnalysis"
_format 
"html"
_locale 
"en"
_stopwatch_token 
"a6a227"

AppController :: renderHeader (token = 182447)

Key Value
_controller 
"App\Controller\AppController::renderHeader"
_format 
"html"
_locale 
"en"
_stopwatch_token 
"4659fd"
slug 
"home"

ArticleController :: trendingArticle (token = 3344fc)

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"App\Controller\ArticleController::trendingArticle"
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"html"
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"en"
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"6d0b30"
category 
"Science"

ArticleController :: relatedArticles (token = 0c7851)

Key Value
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"App\Controller\ArticleController::relatedArticles"
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"html"
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"en"
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"61e76f"
current_article 
App\Entity\Article {#1094
  -id: 3528
  -title: "Probiotic Pros and Cons"
  -slug: "probiotic-pros-and-cons"
  -introtext: "<p>I will avoid any semblance of suspense or drama here: I am a proponent of probiotics.&nbsp;I take one daily.&nbsp;I even helped formulate one, uniquely positioned for use at night.</p>\r\n"
  -content: """
    \r\n
    <p>My personal case is just an anecdote, but like all clinical anecdotes- it matters a lot to the person affected, in this case- me.&nbsp;As an adult, I developed a mild sensitivity to nuts; I would get some abdominal pain after eating them.&nbsp;As walnuts are a favored entry in my concept of a “<a href="https://www.huffpost.com/entry/diet-and-nutrition_b_5458856" target="_blank" rel="nofollow noopener">complete breakfast</a>,” and raw almonds on my short list of preferred snacks, this was quite annoying.&nbsp;I tried a good, multi-strain probiotic, and the problem went away.&nbsp;I enjoy walnuts, almonds, other nuts- and my daily (nightly) probiotic ever since.</p>\r\n
    <p>There’s just a bit more to my personal story, too- namely, the reason why I might need a probiotic in the first place.&nbsp;I do all the things that should produce a fairly optimal microbiome- the ecosystem of diverse bacteria living on and in us- without recourse to ingested bacteria (that, in essence, is what probiotics are).&nbsp;I&nbsp;<a href="https://www.menshealth.com/health/a26142620/how-to-avoid-getting-sick/" target="_blank" rel="nofollow noopener">eat optimally, exercise daily</a>, avoid toxic exposures to the best of my ability.</p>\r\n
    <p>But I live in the modern world, and that’s enough to challenge and perhaps even preclude an entirely robust microbiome.&nbsp;I don’t need to take antibiotics to be exposed to them; trace amounts suffuse our food supply.&nbsp;The same is now true of pesticide residues, herbicide residues, and miscellaneous industrial toxins.&nbsp;Eating organic does not fully avoid these exposures, although it reduces them, because once contamination reaches a certain distribution, there is no escaping it until or unless we produce our food on a new and pristine planet.&nbsp;Don’t hold your breath.</p>\r\n
    <p>So, however good our practices, we and our microbiome are challenged by the ways we have adulterated the once pristine environments on this planet, and inescapably so.&nbsp;A probiotic is a logical counter-measure.</p>\r\n
    <p>With that as a prelude, what warrants the mention of “cons”?&nbsp;There are many potential entries here, including uncertainty about which are the best bacterial strains for whom; whether or not bacteria ingested for health benefit could ever produce direct harm in those with compromised immunity; and the risk of producing an imbalance in bacterial colonies with an attempt to do the converse.&nbsp;In other words, file the “law of unintended consequences” on the list of cons worthy, at least, of consideration.</p>\r\n
    <p>But a recent provocation in the peer-reviewed literature gives us a far more specific concern to address.&nbsp;A&nbsp;<a href="https://www.cell.com/cell/pdf/S0092-8674(18)31108-5.pdf" target="_blank" rel="nofollow noopener">study published in the prestigious journal&nbsp;<em>Cell</em></a>&nbsp;several months ago, and spawning&nbsp;<a href="http://www.bbc.com/future/story/20190124-is-it-worth-taking-probiotics-after-antibiotics" target="_blank" rel="nofollow noopener">media reaction</a>&nbsp;and academic&nbsp;<a href="https://jamanetwork.com/journals/jama/fullarticle/2723633" target="_blank" rel="nofollow noopener">commentary</a>&nbsp;ever since, reported on the effects of probiotics following a course of antibiotics.&nbsp;</p>\r\n
    <p>The researchers gave antibiotics to both mice, and then humans, not to treat any disease- but to disrupt the microbiome.&nbsp;They then followed that disruption with probiotics delivering select strains, and evaluated the effects on the intestinal lining and the reconstitution of a balanced, healthy microbiome.</p>\r\n
    <p>The punch line was that compared to a control group, probiotics interfered with the recovery of gut mucosa, and delayed the microbiome recovery- exactly opposite the intended effects. (Of note, fecal transplantation did accelerate recovery.)&nbsp;</p>\r\n
    <p>I have generally recommended probiotics to patients and family as part of a post-antibiotic recovery plan, and yes, absolutely, I am reconsidering that now.&nbsp;Science evolves incrementally, and scientists are duty bound to keep pace.&nbsp;As an aside, one way to&nbsp;<a href="https://www.amazon.com/Truth-About-Food-Pandas-Bamboozled-ebook/dp/B07H8N32NX" target="_blank" rel="nofollow noopener">differentiate reliable and informed guidance from propaganda</a>&nbsp;is to ask this question:&nbsp;<em>does this source ever respond to new evidence with a change of mind/opinion/recommendation?&nbsp;</em>The answer should certainly not be “every time,” because that suggests the source has no stable foundation of knowledge predicated on the weight of evidence in the first place.&nbsp;But if the answer is “never,” you are in the hands of a huckster,&nbsp;<a href="https://www.brainyquote.com/quotes/bertrand_russell_121392" target="_blank" rel="nofollow noopener">fool, or fanatic</a>.&nbsp;Step away slowly, and whatever you do- resist any temptation to reach for your credit card.</p>\r\n
    <p>Back to the probiotic study- how might we make sense of the finding, assuming that the general case for probiotics as microbiome support is valid?&nbsp;For those wanting the recondite, mechanistic considerations, I commend to you the study in&nbsp;<em>Cell</em>, where those are discussed by the authors.&nbsp;For our purposes here, I will make use of a simple analogy.</p>\r\n
    <p>The goal of probiotics is to achieve a healthy, optimal balance among the bacterial colonies constituting the microbiome.&nbsp;The goal of a balancing pole in the hands of a tightrope walker is to achieve an optimal, healthy balance that prevents her/him from falling off that narrow perch.</p>\r\n
    <p>A balancing pole will do no good in the hands of someone not qualified to walk that rope in the first place.&nbsp;Similarly, probiotics may have unexpected, unintended, and untoward effects depending on context.&nbsp;They no doubt interact with other exposures, from diet to drugs, genes to germs, just as the balancing pole interacts with the aptitudes, training, and constitution of the walker.&nbsp;All of this argues for a carefully personalized approach to probiotic use, a case the&nbsp;<em>Cell</em>&nbsp;authors make.</p>\r\n
    <p>Even more flagrantly, a balancing pole placed across the body of a tightrope walker crumpled and bleeding on the ground after a fall would add something of an insult, and obviously no benefit at all, to such injury.&nbsp;The utility of the pole in achieving balance would not pertain to recovery after the injurious loss of balance.&nbsp;Perhaps the same is true of probiotics after antibiotics.&nbsp;Perhaps the intestines require the same initial period of convalescence as the fallen walker.&nbsp;The pole, and probiotics, are then once more useful only after that first, unperturbed recovery.</p>\r\n
    <p>This is speculation on my part, but that is perhaps the principal conclusion here.&nbsp;We have many good arguments for probiotics, founded in science and sense.&nbsp;We have evidence that they can be used to&nbsp;<a href="https://www.ncbi.nlm.nih.gov/pubmed/29383669" target="_blank" rel="nofollow noopener">fight dangerous infections</a>, and perhaps even protect&nbsp;<a href="https://www.dailymail.co.uk/health/article-6667337/Gut-bacteria-does-cause-depression.html?ito=email_share_article-top" target="_blank" rel="nofollow noopener">mental health</a>.&nbsp;But we have doubts, gaps in our knowledge, and&nbsp;<a href="https://www.nutritionaction.com/daily/dietary-supplements/popular-probiotic-flunks-a-test/" target="_blank" rel="nofollow noopener">precautionary considerations</a>, too.&nbsp;Informed speculation is the best we can do at present.</p>\r\n
    <p>I remain, as noted at the start, a proponent- and will keep taking my probiotic routinely before bed (and enjoying walnuts and almonds).&nbsp;But I will stop recommending probiotics routinely right after antibiotics, and I will keep track of the evidence in this area as it accrues.&nbsp;I will change my mind, and my behavior, in tandem with the evolving evidence, as warranted.</p>\r\n
    <p>The intent of probiotic use is to achieve and maintain a healthy balance in the microbiome.&nbsp;A balanced perspective on the relevant evidence as it comes in, with all due consideration of both pros and cons, is the only reliable way to get there from here.</p>
    """
  -user: Proxies\__CG__\App\Entity\User {#1092 …}
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    date: 2019-02-08 19:39:11.0 UTC (+00:00)
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  -metakey: ""
  -metadesc: "I will avoid any semblance of suspense or drama here: I am a proponent of probiotics.\u{A0}I take one daily.\u{A0}I even helped formulate one, uniquely positioned for use at night."
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AppController :: renderFooter (token = 3233cf)

Key Value
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"App\Controller\AppController::renderFooter"
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"html"
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"en"
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"39f1b8"

CookieController :: renderCookie (token = 7ad3fa)

Key Value
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"App\Controller\CookieController::renderCookie"
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"html"
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"en"
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"e65d2e"