ArticleController :: show
Request
GET Parameters
None
POST Parameters
None
Uploaded Files
None
Request Attributes
| Key | Value |
|---|---|
| _controller | "App\Controller\ArticleController::show" |
| _firewall_context | "security.firewall.map.context.main" |
| _links | Symfony\Component\WebLink\GenericLinkProvider {#3614 -links: [ 3735 => Symfony\Component\WebLink\Link {#3735 -href: "/build/runtime.js" -rel: [ "preload" => "preload" ] -attributes: [ "as" => "script" ] } 3733 => Symfony\Component\WebLink\Link {#3733 -href: "/build/644.js" -rel: [ "preload" => "preload" ] -attributes: [ "as" => "script" ] } 3732 => Symfony\Component\WebLink\Link {#3732 -href: "/build/502.js" -rel: [ "preload" => "preload" ] -attributes: [ "as" => "script" ] } 3731 => Symfony\Component\WebLink\Link {#3731 -href: "/build/app.js" -rel: [ "preload" => "preload" ] -attributes: [ "as" => "script" ] } 3730 => Symfony\Component\WebLink\Link {#3730 -href: "/build/view-more.js" -rel: [ "preload" => "preload" ] -attributes: [ "as" => "script" ] } 3729 => Symfony\Component\WebLink\Link {#3729 -href: "/build/term-condition.js" -rel: [ "preload" => "preload" ] -attributes: [ "as" => "script" ] } 3728 => Symfony\Component\WebLink\Link {#3728 -href: "/build/contact.js" -rel: [ "preload" => "preload" ] -attributes: [ "as" => "script" ] } 3727 => Symfony\Component\WebLink\Link {#3727 -href: "/build/scroll-infinite-article.js" -rel: [ "preload" => "preload" ] -attributes: [ "as" => "script" ] } 3726 => Symfony\Component\WebLink\Link {#3726 -href: "/build/app.css" -rel: [ "preload" => "preload" ] -attributes: [ "as" => "style" ] } 3725 => Symfony\Component\WebLink\Link {#3725 -href: "/build/cookie-style.css" -rel: [ "preload" => "preload" ] -attributes: [ "as" => "style" ] } 3724 => Symfony\Component\WebLink\Link {#3724 -href: "/build/term-condition-css.css" -rel: [ "preload" => "preload" ] -attributes: [ "as" => "style" ] } 3723 => Symfony\Component\WebLink\Link {#3723 -href: "/build/contact-css.css" -rel: [ "preload" => "preload" ] -attributes: [ "as" => "style" ] } 3722 => Symfony\Component\WebLink\Link {#3722 -href: "/build/comment-css.css" -rel: [ "preload" => "preload" ] -attributes: [ "as" => "style" ] } ] } |
| _route | "article_show" |
| _route_params | [ "category" => "global-economy" "slug" => "biologics-and-biosimilars-a-test-for-intellectual-property" ] |
| _security_firewall_run | "_security_main" |
| _stopwatch_token | "aa0ef8" |
| category | "global-economy" |
| slug | "biologics-and-biosimilars-a-test-for-intellectual-property" |
Request Headers
| Header | Value |
|---|---|
| accept | "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" |
| accept-encoding | "gzip, deflate, br, zstd" |
| cache-control | "no-cache" |
| connection | "close" |
| host | "rct.dev.bbntimes.com" |
| pragma | "no-cache" |
| sec-ch-ua | ""HeadlessChrome";v="129", "Not=A?Brand";v="8", "Chromium";v="129"" |
| sec-ch-ua-mobile | "?0" |
| sec-ch-ua-platform | ""Windows"" |
| sec-fetch-dest | "document" |
| sec-fetch-mode | "navigate" |
| sec-fetch-site | "none" |
| sec-fetch-user | "?1" |
| upgrade-insecure-requests | "1" |
| user-agent | "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" |
| x-php-ob-level | "1" |
Request Content
Request content not available (it was retrieved as a resource).
Response
Response Headers
| Header | Value |
|---|---|
| cache-control | "no-cache, private" |
| content-type | "text/html; charset=UTF-8" |
| date | "Sat, 26 Apr 2025 15:09:53 GMT" |
| link | "</build/runtime.js>; rel="preload"; as="script",</build/644.js>; rel="preload"; as="script",</build/502.js>; rel="preload"; as="script",</build/app.js>; rel="preload"; as="script",</build/view-more.js>; rel="preload"; as="script",</build/term-condition.js>; rel="preload"; as="script",</build/contact.js>; rel="preload"; as="script",</build/scroll-infinite-article.js>; rel="preload"; as="script",</build/app.css>; rel="preload"; as="style",</build/cookie-style.css>; rel="preload"; as="style",</build/term-condition-css.css>; rel="preload"; as="style",</build/contact-css.css>; rel="preload"; as="style",</build/comment-css.css>; rel="preload"; as="style"" |
| x-debug-token | "29f31c" |
Cookies
Request Cookies
No request cookies
Response Cookies
No response cookies
Session 11
Session Metadata
| Key | Value |
|---|---|
| Created | "Sat, 26 Apr 25 15:09:52 +0000" |
| Last used | "Sat, 26 Apr 25 15:09:52 +0000" |
| Lifetime | 0 |
Session Attributes
| Attribute | Value |
|---|---|
| _csrf/https-comment | "ziSTQFEauyfZaH2prHmDxl2YTI0zKTOxThSadDbcRNY" |
| _csrf/https-cookie_accept | "6tBKvMdRzqQn4uZ7Hcu7ERxN5Y65P-Th5MPgXwYxoHI" |
Session Usage
11
Usages
Stateless check enabled
| Usage |
|---|
Symfony\Component\Security\Csrf\TokenStorage\SessionTokenStorage:76
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Symfony\Component\Security\Csrf\TokenStorage\SessionTokenStorage:79
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Symfony\Component\Security\Csrf\TokenStorage\SessionTokenStorage:69
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Symfony\Component\Security\Csrf\TokenStorage\SessionTokenStorage:52
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Symfony\Component\Security\Csrf\TokenStorage\SessionTokenStorage:56
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Flashes
Flashes
No flash messages were created.
Server Parameters
Server Parameters
Defined in .env
| Key | Value |
|---|---|
| APP_ENV | "dev" |
| APP_SECRET | "0a988e63f011514eaabfc650b599af4d" |
| CORS_ALLOW_ORIGIN | "*" |
| DATABASE_URL | "mysql://bbndb_rctuser:33F5W25z40or0f7@localhost:3306/rct_bbntimes" |
| GOOGLE_RECAPTCHA_SECRET_KEY | "6LdV5fgpAAAAANxzTG8ZMfIjil1wu-1vrQvnUt-x" |
| GOOGLE_RECAPTCHA_SITE_KEY | "6LdV5fgpAAAAAENKcn73MJAhQrbtQeqgyC4wDLMP" |
| MAILER_DSN | "smtp://no-reply%40rct.dev.bbntimes.com:Bl6%26gLD48%26Of919@rct.dev.bbntimes.com:465" |
| MARIADB_PASSWORD | "i!87pK&!85ezc8" |
Defined as regular env variables
| Key | Value |
|---|---|
| APP_DEBUG | "1" |
| BASE | "/public" |
| CONTEXT_DOCUMENT_ROOT | "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com" |
| CONTEXT_PREFIX | "" |
| DOCUMENT_ROOT | "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com" |
| FCGI_ROLE | "RESPONDER" |
| GATEWAY_INTERFACE | "CGI/1.1" |
| HTTPS | "on" |
| HTTP_ACCEPT | "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" |
| HTTP_ACCEPT_ENCODING | "gzip, deflate, br, zstd" |
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| HTTP_HOST | "rct.dev.bbntimes.com" |
| HTTP_PRAGMA | "no-cache" |
| HTTP_SEC_CH_UA | ""HeadlessChrome";v="129", "Not=A?Brand";v="8", "Chromium";v="129"" |
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| PASSENGER_COMPILE_NATIVE_SUPPORT_BINARY | "0" |
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| PATH | "/usr/local/sbin:/usr/local/bin:/usr/sbin:/usr/bin:/sbin:/bin:/snap/bin" |
| PHP_SELF | "/public/index.php" |
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| PP_CUSTOM_PHP_INI | "/var/www/vhosts/system/rct.dev.bbntimes.com/etc/php.ini" |
| QUERY_STRING | "" |
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| REDIRECT_REDIRECT_SCRIPT_URL | "/global-economy/biologics-and-biosimilars-a-test-for-intellectual-property" |
| REDIRECT_REDIRECT_SSL_TLS_SNI | "rct.dev.bbntimes.com" |
| REDIRECT_REDIRECT_STATUS | "200" |
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| REDIRECT_SCRIPT_URI | "https://rct.dev.bbntimes.com/global-economy/biologics-and-biosimilars-a-test-for-intellectual-property" |
| REDIRECT_SCRIPT_URL | "/global-economy/biologics-and-biosimilars-a-test-for-intellectual-property" |
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| current_article | App\Entity\Article {#1094 -id: 13513 -title: "Biologics and Biosimilars: A Test for Intellectual Property" -slug: "biologics-and-biosimilars-a-test-for-intellectual-property" -introtext: "<p>The fundamental tradeoff of <a href="companies/understanding-the-basics-of-patents" target="_blank" rel="noopener">intellectual property</a> rights–like patents and copyrights–is that the inventor gets a government-protected monopoly for a period of time, as an incentive for innovation, but then the innovation passes into the public domain. For example, this is the moment when generic equivalents of pharmaceuticals can start competing with brand-name drugs.</p>\r\n" -content: """ \r\n <p>The period when a lucrative invention shifts into the public domain is primed for politics and strategy, as the incumbent firm tries to hold on to its leading competitive position. In one famous example, the US Congress passed in 1998 what became known as the “Mickey Mouse Protection Act,” which extended copyright protection for Mickey and many lesser-known creations to last for 95 years–an extension of 21 years from the previous rule. A few decades ago, when generic drugs started to take over from previously patented drugs, there was a storm of litigation and antitrust action around questions like whether generics had to go through similar testing for safety and efficacy by the Food and Drug Administration, and how to judge whether a generic drug was the same–or perhaps just a little different–than the previously patented drug.</p>\r\n <p>Now, 91% of US prescriptions are for ge<a href="https://accessiblemeds.org/sites/default/files/2022-09/AAM-2022-Generic-Biosimilar-Medicines-Savings-Report.pdf" target="_blank" rel="nofollow noopener">neric drugs. By one estimate, this saves over $370 billion per year for US health care consumers</a>. But almost all of those generic drugs are “small molecule” drugs, which essentially means that they are created by chemistry. Starting a couple of decades ago, a new wave of “biologic” drugs arrived. These begin by isolating certain components from humans, animals, or microorganisms, and then growing them through biotechnology or related techniques. They include <a href="https://www.fda.gov/about-fda/center-biologics-evaluation-and-research-cber/what-are-biologics-questions-and-answers" target="_blank" rel="nofollow noopener">“vaccines, blood and blood components, allergenics, somatic cells, gene therapy, tissues, and recombinant therapeutic proteins.”</a> As one example, the COVID vaccines are biologics. The<a href="https://tradeoffs.org/2023/01/26/humira-biosimilar-drug-prices/" target="_blank" rel="nofollow noopener"> highest-revenue prescription drug of all time, AbbVie’</a>s <a href="https://tradeoffs.org/2023/01/26/humira-biosimilar-drug-prices/" target="_blank" rel="nofollow noopener">Humira</a>–an injectable treatment for autoimmune conditions like rheumatoid arthritis–is a biologic. It can cost some patients $70,000 per year.</p>\r\n <p>A number of biosimilars are remarkable advances in health care, and bring substantial benefits to patients. Many of them also have very high prices. Indeed, t<a href="https://www.ajmc.com/view/projected-us-savings-from-biosimilars-2021-2025" target="_blank" rel="nofollow noopener">he rough estimates seem to be that biologics account for 2% of US prescriptions for drugs, but 40% of total spending on prescription drugs</a>. Of t<a href="https://www.dcatvci.org/features/pharma-pulse-top-selling-small-molecules-biologics/" target="_blank" rel="nofollow noopener">he top 10 prescription drugs in the US in 2021 by revenue, seven are biologics</a>–including two versions of the COVID vaccine. Industry projections are that <a href="https://www.pharmaceutical-technology.com/comment/biologic-sales-small-molecule-sales/" target="_blank" rel="nofollow noopener">in a few years, annual revenues from biologics will exceed those for small-molecule drugs by $100 per year or more</a>. Again, part of the reason is that so many small-molecule drugs are now available in generic form, while many leading biologics are still on patent. Humira is just about to go off patent this year.</p>\r\n <p>The generic equivalents for biologic drugs are called “biosimilars,” because the chemistry of these (“large molecule”) biologics often isn’t easy to define. They are often hard to manufacture, and susceptible to heat or contamination. As a result, the producers of the original biologics often obtain patents not just on a therapeutic molecule, but on a variety of manufacturing techniques, each of which produced slightly different chemical outcomes that can be patented as well.</p>\r\n <p>For example, the AbbVie patent on adalimumab, the key ingredient in Humira, actually expired back in 2016. But given new manufacturing techniques and variations on the original formulation, <a href="https://journalofethics.ama-assn.org/article/why-are-biosimilars-not-living-their-promise-us/2019-08" target="_blank" rel="nofollow noopener">AbbVie has actually obtained more than 100 patents related to Humira</a>. In the antitrust biz, this is sometimes called a <a href="https://conversableeconomist.com/2019/11/22/the-return-of-the-patent-thicket/" target="_blank" rel="nofollow noopener">“patent thicket”</a>–a term which refers to an ever-evolving body of patents, with old ones expiring and new ones coming into play, thus blocking new competition on an ongoing basis.</p>\r\n <p>Back in 2010, the Biologics Price Competition and Innovation Act became law, with the goal of defining a path for biosimilar drugs to replace the original brand-name biologics, as patents expire, in the same say that generics have replaced so many small-molecule drugs in the last couple of decades. <a href="https://journalofethics.ama-assn.org/article/why-are-biosimilars-not-living-their-promise-us/2019-08" target="_blank" rel="nofollow noopener">The law is based on language about whether the biosimilar is “highly similar” to the original, with no “clinically meaningful differences.”</a> But of course, terms like “highly similar” and “meaningful differences” are basically catnip for lawyers, especially when billions of dollars of sales are at stake.</p>\r\n <p>I don’t have any deep insights into how to write the rules governing when biosimilars can replace the original biologics. I readily acknowledge that there are some hard questions here, because we aren’t dealing with precise chemistry and small molecule drugs in this situation. There are legitimate questions about biosimilars being produced in safe ways.</p>\r\n <p>But the overall goal here seems fairly clear: when patent protection expires, reasonably easy entry should be possible. If the rules for new biosimilars require extensive re-testing and long-term tests on patients, it will be much harder for biosimilars to gain a foothold. In some cases, makers of the original brand-name biologics also managed to sign exclusive deals with health care providers, where the providers agreed to use only the original biologic and to shun biosimilars. There are now <a href="https://accessiblemeds.org/sites/default/files/2022-09/AAM-2022-Generic-Biosimilar-Medicines-Savings-Report.pdf" target="_blank" rel="nofollow noopener">22 biosimilars approved for patients, with another seven scheduled to launch this year</a>. But there have been <a href="https://journalofethics.ama-assn.org/article/why-are-biosimilars-not-living-their-promise-us/2019-08" target="_blank" rel="nofollow noopener">essays in medical journals for several years </a>now lamenting the slow pace at which biosimilars have been approved.</p>\r\n <p>At present, Humira is the biggest test. At least eight other drug companies have plans to launch biosimilars. But along with the patent thicket that AbbVie has constructed around Humira, AbbVie is introducing two new biologics with similar effects, different active ingredients–and patent protection. Under current rules, a pharmacist can swap in a generic drug for a brand-name without needing a new prescription, but for biologics, a new prescription naming the biosimilar drug is needed. In some ways, the question of whether biosimilar competitors for Humira can become established in the market is a test case for the biosimilar industry as a whole, in the sense that it will affect whether firms see the biosimilar market as worth pursuing. But one big health care system is apparently ready to switch: <a href="https://tradeoffs.org/2023/01/26/humira-biosimilar-drug-prices/" target="_blank" rel="nofollow noopener">“David Chen, who directs specialty drug use for Kaiser Permanente, said the insurer plans to stop covering Humira by the end of 2023. He expects at least 90 percent of patients to switch to the biosimilar alternative, and said Kaiser should save hundreds of millions of dollars a year.”</a></p>\r\n <p>“<a href="https://tradeoffs.org/2023/01/26/humira-biosimilar-drug-prices/" target="_blank" rel="noopener">A golden opportunity for a beleaguered biosimilars market”</a> (Trade Offs, January 26, 2023).</p> """ -user: Proxies\__CG__\App\Entity\User {#1092 …} -createdAt: DateTime @1675687537 {#1145 : 2023-02-06 12:45:37.0 UTC (+00:00) } -updatedAt: DateTime @1680196517 {#1150 : 2023-03-30 17:15:17.0 UTC (+00:00) } -deletedAt: null -category: App\Entity\Category {#445 …} -status: "published" -imageCard: Proxies\__CG__\App\Entity\File {#1184 …} -ImageHeader: Proxies\__CG__\App\Entity\File {#1184 …} -featured: false -mainView: false -clicks: 1356 -comments: Doctrine\ORM\PersistentCollection {#1125 …} -reviewed_at: DateTime @1675687537 {#1148 : 2023-02-06 12:45:37.0 UTC (+00:00) } -metakey: "Biologics and Biosimilars: A Test for Intellectual Property" -metadesc: "The fundamental tradeoff of\u{A0}intellectual property\u{A0}rights–like patents and copyrights–is that the inventor gets a government-protected monopoly for a period of time, as an incentive for innovation, but then the innovation passes into the public domain. For example, this is the moment when generic equivalents of pharmaceuticals can start competing with brand-name drugs." -robots: null -publishedAt: DateTime @1675687537 {#1147 : 2023-02-06 12:45:37.0 UTC (+00:00) } -canonical: null -superTag: null } |
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