Symfony Profiler

ArticleController :: show

Request

GET Parameters

None

POST Parameters

None

Uploaded Files

None

Request Attributes

Key	Value
_controller	"App\Controller\ArticleController::show"
_firewall_context	"security.firewall.map.context.main"
_links	Symfony\Component\WebLink\GenericLinkProvider {#3649-links: [ 3770 => Symfony\Component\WebLink\Link {#3770 -href: "/build/runtime.js" -rel: [ "preload" => "preload" ] -attributes: [ "as" => "script" ] } 3768 => Symfony\Component\WebLink\Link {#3768 -href: "/build/644.js" -rel: [ "preload" => "preload" ] -attributes: [ "as" => "script" ] } 3767 => Symfony\Component\WebLink\Link {#3767 -href: "/build/502.js" -rel: [ "preload" => "preload" ] -attributes: [ "as" => "script" ] } 3766 => Symfony\Component\WebLink\Link {#3766 -href: "/build/app.js" -rel: [ "preload" => "preload" ] -attributes: [ "as" => "script" ] } 3765 => Symfony\Component\WebLink\Link {#3765 -href: "/build/view-more.js" -rel: [ "preload" => "preload" ] -attributes: [ "as" => "script" ] } 3764 => Symfony\Component\WebLink\Link {#3764 -href: "/build/term-condition.js" -rel: [ "preload" => "preload" ] -attributes: [ "as" => "script" ] } 3763 => Symfony\Component\WebLink\Link {#3763 -href: "/build/contact.js" -rel: [ "preload" => "preload" ] -attributes: [ "as" => "script" ] } 3762 => Symfony\Component\WebLink\Link {#3762 -href: "/build/scroll-infinite-article.js" -rel: [ "preload" => "preload" ] -attributes: [ "as" => "script" ] } 3761 => Symfony\Component\WebLink\Link {#3761 -href: "/build/app.css" -rel: [ "preload" => "preload" ] -attributes: [ "as" => "style" ] } 3760 => Symfony\Component\WebLink\Link {#3760 -href: "/build/cookie-style.css" -rel: [ "preload" => "preload" ] -attributes: [ "as" => "style" ] } 3759 => Symfony\Component\WebLink\Link {#3759 -href: "/build/term-condition-css.css" -rel: [ "preload" => "preload" ] -attributes: [ "as" => "style" ] } 3758 => Symfony\Component\WebLink\Link {#3758 -href: "/build/contact-css.css" -rel: [ "preload" => "preload" ] -attributes: [ "as" => "style" ] } 3757 => Symfony\Component\WebLink\Link {#3757 -href: "/build/comment-css.css" -rel: [ "preload" => "preload" ] -attributes: [ "as" => "style" ] } ]}
_route	"article_show"
_route_params	[`"category" => "science" "slug" => "new-harvard-anticancer-molecule-is-a-synthetic-biology-breakthrough"`]
_security_firewall_run	"_security_main"
_stopwatch_token	"120fc9"
category	"science"
slug	"new-harvard-anticancer-molecule-is-a-synthetic-biology-breakthrough"

Request Headers

Header	Value
accept	"/"
accept-encoding	"gzip, br, zstd, deflate"
connection	"close"
host	"rct.dev.bbntimes.com"
user-agent	"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)"
x-php-ob-level	"1"

Request Content

Request content not available (it was retrieved as a resource).

Response

Response Headers

Header	Value
cache-control	"no-cache, private"
content-type	"text/html; charset=UTF-8"
date	"Sat, 22 Feb 2025 13:49:06 GMT"
link	"</build/runtime.js>; rel="preload"; as="script",</build/644.js>; rel="preload"; as="script",</build/502.js>; rel="preload"; as="script",</build/app.js>; rel="preload"; as="script",</build/view-more.js>; rel="preload"; as="script",</build/term-condition.js>; rel="preload"; as="script",</build/contact.js>; rel="preload"; as="script",</build/scroll-infinite-article.js>; rel="preload"; as="script",</build/app.css>; rel="preload"; as="style",</build/cookie-style.css>; rel="preload"; as="style",</build/term-condition-css.css>; rel="preload"; as="style",</build/contact-css.css>; rel="preload"; as="style",</build/comment-css.css>; rel="preload"; as="style""
x-debug-token	"46c516"

Cookies

Request Cookies

No request cookies

Response Cookies

No response cookies

Session 11

Session Metadata

Key	Value
Created	"Sat, 22 Feb 25 13:49:05 +0000"
Last used	"Sat, 22 Feb 25 13:49:05 +0000"
Lifetime	0

Session Attributes

Attribute	Value
_csrf/https-comment	"mNniA5SXOO8NiGJ-NTQFrUrA7TguQBa99Iw0PStFgPg"
_csrf/https-cookie_accept	"98ydXDduH8MHuK5A5Kq_Dzi-84pNouFoqQcdcNnDpyA"

Session Usage

11 Usages

Stateless check enabled

Usage
Symfony\Component\Security\Csrf\TokenStorage\SessionTokenStorage:76 Show trace [[ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/security-csrf/TokenStorage/SessionTokenStorage.php" "line" => 76 "function" => "start" "class" => "Symfony\Component\HttpFoundation\Session\Session" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/security-csrf/CsrfTokenManager.php" "line" => 69 "function" => "hasToken" "class" => "Symfony\Component\Security\Csrf\TokenStorage\SessionTokenStorage" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/form/Extension/Csrf/Type/FormTypeCsrfExtension.php" "line" => 82 "function" => "getToken" "class" => "Symfony\Component\Security\Csrf\CsrfTokenManager" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/form/ResolvedFormType.php" "line" => 134 "function" => "finishView" "class" => "Symfony\Component\Form\Extension\Csrf\Type\FormTypeCsrfExtension" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/form/Extension/DataCollector/Proxy/ResolvedTypeDataCollectorProxy.php" "line" => 95 "function" => "finishView" "class" => "Symfony\Component\Form\ResolvedFormType" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/form/ResolvedFormType.php" "line" => 128 "function" => "finishView" "class" => "Symfony\Component\Form\Extension\DataCollector\Proxy\ResolvedTypeDataCollectorProxy" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/form/Extension/DataCollector/Proxy/ResolvedTypeDataCollectorProxy.php" "line" => 95 "function" => "finishView" "class" => "Symfony\Component\Form\ResolvedFormType" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/form/Form.php" "line" => 908 "function" => "finishView" "class" => "Symfony\Component\Form\Extension\DataCollector\Proxy\ResolvedTypeDataCollectorProxy" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/src/Controller/ArticleController.php" "line" => 220 "function" => "createView" "class" => "Symfony\Component\Form\Form" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpKernel.php" "line" => 181 "function" => "show" "class" => "App\Controller\ArticleController" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpKernel.php" "line" => 76 "function" => "handleRaw" "class" => "Symfony\Component\HttpKernel\HttpKernel" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/Kernel.php" "line" => 197 "function" => "handle" "class" => "Symfony\Component\HttpKernel\HttpKernel" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/runtime/Runner/Symfony/HttpKernelRunner.php" "line" => 35 "function" => "handle" "class" => "Symfony\Component\HttpKernel\Kernel" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/autoload_runtime.php" "line" => 29 "function" => "run" "class" => "Symfony\Component\Runtime\Runner\Symfony\HttpKernelRunner" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/public/index.php" "line" => 5 "args" => [ "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/autoload_runtime.php" ] "function" => "require_once" ]]
Symfony\Component\Security\Csrf\TokenStorage\SessionTokenStorage:79 Show trace [[ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/security-csrf/TokenStorage/SessionTokenStorage.php" "line" => 79 "function" => "has" "class" => "Symfony\Component\HttpFoundation\Session\Session" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/security-csrf/CsrfTokenManager.php" "line" => 69 "function" => "hasToken" "class" => "Symfony\Component\Security\Csrf\TokenStorage\SessionTokenStorage" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/form/Extension/Csrf/Type/FormTypeCsrfExtension.php" "line" => 82 "function" => "getToken" "class" => "Symfony\Component\Security\Csrf\CsrfTokenManager" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/form/ResolvedFormType.php" "line" => 134 "function" => "finishView" "class" => "Symfony\Component\Form\Extension\Csrf\Type\FormTypeCsrfExtension" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/form/Extension/DataCollector/Proxy/ResolvedTypeDataCollectorProxy.php" "line" => 95 "function" => "finishView" "class" => "Symfony\Component\Form\ResolvedFormType" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/form/ResolvedFormType.php" "line" => 128 "function" => "finishView" "class" => "Symfony\Component\Form\Extension\DataCollector\Proxy\ResolvedTypeDataCollectorProxy" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/form/Extension/DataCollector/Proxy/ResolvedTypeDataCollectorProxy.php" "line" => 95 "function" => "finishView" "class" => "Symfony\Component\Form\ResolvedFormType" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/form/Form.php" "line" => 908 "function" => "finishView" "class" => "Symfony\Component\Form\Extension\DataCollector\Proxy\ResolvedTypeDataCollectorProxy" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/src/Controller/ArticleController.php" "line" => 220 "function" => "createView" "class" => "Symfony\Component\Form\Form" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpKernel.php" "line" => 181 "function" => "show" "class" => "App\Controller\ArticleController" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpKernel.php" "line" => 76 "function" => "handleRaw" "class" => "Symfony\Component\HttpKernel\HttpKernel" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/Kernel.php" "line" => 197 "function" => "handle" "class" => "Symfony\Component\HttpKernel\HttpKernel" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/runtime/Runner/Symfony/HttpKernelRunner.php" "line" => 35 "function" => "handle" "class" => "Symfony\Component\HttpKernel\Kernel" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/autoload_runtime.php" "line" => 29 "function" => "run" "class" => "Symfony\Component\Runtime\Runner\Symfony\HttpKernelRunner" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/public/index.php" "line" => 5 "args" => [ "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/autoload_runtime.php" ] "function" => "require_once" ]]
Symfony\Component\Security\Csrf\TokenStorage\SessionTokenStorage:69 Show trace [[ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/security-csrf/TokenStorage/SessionTokenStorage.php" "line" => 69 "function" => "set" "class" => "Symfony\Component\HttpFoundation\Session\Session" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/security-csrf/CsrfTokenManager.php" "line" => 74 "function" => "setToken" "class" => "Symfony\Component\Security\Csrf\TokenStorage\SessionTokenStorage" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/form/Extension/Csrf/Type/FormTypeCsrfExtension.php" "line" => 82 "function" => "getToken" "class" => "Symfony\Component\Security\Csrf\CsrfTokenManager" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/form/ResolvedFormType.php" "line" => 134 "function" => "finishView" "class" => "Symfony\Component\Form\Extension\Csrf\Type\FormTypeCsrfExtension" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/form/Extension/DataCollector/Proxy/ResolvedTypeDataCollectorProxy.php" "line" => 95 "function" => "finishView" "class" => "Symfony\Component\Form\ResolvedFormType" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/form/ResolvedFormType.php" "line" => 128 "function" => "finishView" "class" => "Symfony\Component\Form\Extension\DataCollector\Proxy\ResolvedTypeDataCollectorProxy" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/form/Extension/DataCollector/Proxy/ResolvedTypeDataCollectorProxy.php" "line" => 95 "function" => "finishView" "class" => "Symfony\Component\Form\ResolvedFormType" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/form/Form.php" "line" => 908 "function" => "finishView" "class" => "Symfony\Component\Form\Extension\DataCollector\Proxy\ResolvedTypeDataCollectorProxy" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/src/Controller/ArticleController.php" "line" => 220 "function" => "createView" "class" => "Symfony\Component\Form\Form" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpKernel.php" "line" => 181 "function" => "show" "class" => "App\Controller\ArticleController" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpKernel.php" "line" => 76 "function" => "handleRaw" "class" => "Symfony\Component\HttpKernel\HttpKernel" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/Kernel.php" "line" => 197 "function" => "handle" "class" => "Symfony\Component\HttpKernel\HttpKernel" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/runtime/Runner/Symfony/HttpKernelRunner.php" "line" => 35 "function" => "handle" "class" => "Symfony\Component\HttpKernel\Kernel" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/autoload_runtime.php" "line" => 29 "function" => "run" "class" => "Symfony\Component\Runtime\Runner\Symfony\HttpKernelRunner" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/public/index.php" "line" => 5 "args" => [ "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/autoload_runtime.php" ] "function" => "require_once" ]]
Symfony\Component\Security\Csrf\TokenStorage\SessionTokenStorage:52 Show trace [[ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/security-csrf/TokenStorage/SessionTokenStorage.php" "line" => 52 "function" => "has" "class" => "Symfony\Component\HttpFoundation\Session\Session" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/security-csrf/CsrfTokenManager.php" "line" => 70 "function" => "getToken" "class" => "Symfony\Component\Security\Csrf\TokenStorage\SessionTokenStorage" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/form/Extension/Csrf/Type/FormTypeCsrfExtension.php" "line" => 82 "function" => "getToken" "class" => "Symfony\Component\Security\Csrf\CsrfTokenManager" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/form/ResolvedFormType.php" "line" => 134 "function" => "finishView" "class" => "Symfony\Component\Form\Extension\Csrf\Type\FormTypeCsrfExtension" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/form/Extension/DataCollector/Proxy/ResolvedTypeDataCollectorProxy.php" "line" => 95 "function" => "finishView" "class" => "Symfony\Component\Form\ResolvedFormType" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/form/ResolvedFormType.php" "line" => 128 "function" => "finishView" "class" => "Symfony\Component\Form\Extension\DataCollector\Proxy\ResolvedTypeDataCollectorProxy" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/form/Extension/DataCollector/Proxy/ResolvedTypeDataCollectorProxy.php" "line" => 95 "function" => "finishView" "class" => "Symfony\Component\Form\ResolvedFormType" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/form/Form.php" "line" => 908 "function" => "finishView" "class" => "Symfony\Component\Form\Extension\DataCollector\Proxy\ResolvedTypeDataCollectorProxy" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/src/Controller/ArticleController.php" "line" => 222 "function" => "createView" "class" => "Symfony\Component\Form\Form" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpKernel.php" "line" => 181 "function" => "show" "class" => "App\Controller\ArticleController" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpKernel.php" "line" => 76 "function" => "handleRaw" "class" => "Symfony\Component\HttpKernel\HttpKernel" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/Kernel.php" "line" => 197 "function" => "handle" "class" => "Symfony\Component\HttpKernel\HttpKernel" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/runtime/Runner/Symfony/HttpKernelRunner.php" "line" => 35 "function" => "handle" "class" => "Symfony\Component\HttpKernel\Kernel" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/autoload_runtime.php" "line" => 29 "function" => "run" "class" => "Symfony\Component\Runtime\Runner\Symfony\HttpKernelRunner" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/public/index.php" "line" => 5 "args" => [ "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/autoload_runtime.php" ] "function" => "require_once" ]]
Symfony\Component\Security\Csrf\TokenStorage\SessionTokenStorage:56 Show trace [[ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/security-csrf/TokenStorage/SessionTokenStorage.php" "line" => 56 "function" => "get" "class" => "Symfony\Component\HttpFoundation\Session\Session" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/security-csrf/CsrfTokenManager.php" "line" => 70 "function" => "getToken" "class" => "Symfony\Component\Security\Csrf\TokenStorage\SessionTokenStorage" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/form/Extension/Csrf/Type/FormTypeCsrfExtension.php" "line" => 82 "function" => "getToken" "class" => "Symfony\Component\Security\Csrf\CsrfTokenManager" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/form/ResolvedFormType.php" "line" => 134 "function" => "finishView" "class" => "Symfony\Component\Form\Extension\Csrf\Type\FormTypeCsrfExtension" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/form/Extension/DataCollector/Proxy/ResolvedTypeDataCollectorProxy.php" "line" => 95 "function" => "finishView" "class" => "Symfony\Component\Form\ResolvedFormType" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/form/ResolvedFormType.php" "line" => 128 "function" => "finishView" "class" => "Symfony\Component\Form\Extension\DataCollector\Proxy\ResolvedTypeDataCollectorProxy" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/form/Extension/DataCollector/Proxy/ResolvedTypeDataCollectorProxy.php" "line" => 95 "function" => "finishView" "class" => "Symfony\Component\Form\ResolvedFormType" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/form/Form.php" "line" => 908 "function" => "finishView" "class" => "Symfony\Component\Form\Extension\DataCollector\Proxy\ResolvedTypeDataCollectorProxy" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/src/Controller/ArticleController.php" "line" => 222 "function" => "createView" "class" => "Symfony\Component\Form\Form" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpKernel.php" "line" => 181 "function" => "show" "class" => "App\Controller\ArticleController" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpKernel.php" "line" => 76 "function" => "handleRaw" "class" => "Symfony\Component\HttpKernel\HttpKernel" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/Kernel.php" "line" => 197 "function" => "handle" "class" => "Symfony\Component\HttpKernel\HttpKernel" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/runtime/Runner/Symfony/HttpKernelRunner.php" "line" => 35 "function" => "handle" "class" => "Symfony\Component\HttpKernel\Kernel" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/autoload_runtime.php" "line" => 29 "function" => "run" "class" => "Symfony\Component\Runtime\Runner\Symfony\HttpKernelRunner" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/public/index.php" "line" => 5 "args" => [ "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/autoload_runtime.php" ] "function" => "require_once" ]]
Symfony\Component\HttpKernel\DataCollector\RequestDataCollector:69 Show trace [[ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/DataCollector/RequestDataCollector.php" "line" => 69 "function" => "getMetadataBag" "class" => "Symfony\Component\HttpFoundation\Session\Session" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/Profiler/Profiler.php" "line" => 169 "function" => "collect" "class" => "Symfony\Component\HttpKernel\DataCollector\RequestDataCollector" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/EventListener/ProfilerListener.php" "line" => 108 "function" => "collect" "class" => "Symfony\Component\HttpKernel\Profiler\Profiler" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/event-dispatcher/Debug/WrappedListener.php" "line" => 116 "function" => 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Symfony\Component\HttpKernel\DataCollector\RequestDataCollector:72 Show trace [[ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/DataCollector/RequestDataCollector.php" "line" => 72 "function" => "all" "class" => "Symfony\Component\HttpFoundation\Session\Session" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/Profiler/Profiler.php" "line" => 169 "function" => "collect" "class" => "Symfony\Component\HttpKernel\DataCollector\RequestDataCollector" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/EventListener/ProfilerListener.php" "line" => 108 "function" => "collect" "class" => "Symfony\Component\HttpKernel\Profiler\Profiler" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/event-dispatcher/Debug/WrappedListener.php" "line" => 116 "function" => "onKernelResponse" "class" 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"/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/Template.php" "line" => 367 "function" => "displayWithErrorHandling" "class" => "Twig\Template" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/Template.php" "line" => 379 "function" => "display" "class" => "Twig\Template" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/TemplateWrapper.php" "line" => 38 "function" => "render" "class" => "Twig\Template" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/Environment.php" "line" => 280 "function" => "render" "class" => "Twig\TemplateWrapper" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/framework-bundle/Controller/AbstractController.php" "line" => 448 "function" => "render" "class" => "Twig\Environment" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/framework-bundle/Controller/AbstractController.php" "line" => 453 "function" => "doRenderView" "class" => "Symfony\Bundle\FrameworkBundle\Controller\AbstractController" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/framework-bundle/Controller/AbstractController.php" "line" => 253 "function" => "doRender" "class" => "Symfony\Bundle\FrameworkBundle\Controller\AbstractController" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/src/Controller/ArticleController.php" "line" => 277 "function" => "render" "class" => "Symfony\Bundle\FrameworkBundle\Controller\AbstractController" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpKernel.php" "line" => 181 "function" => "show" "class" => "App\Controller\ArticleController" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpKernel.php" "line" => 76 "function" => "handleRaw" "class" => "Symfony\Component\HttpKernel\HttpKernel" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/Kernel.php" "line" => 197 "function" => "handle" "class" => "Symfony\Component\HttpKernel\HttpKernel" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/runtime/Runner/Symfony/HttpKernelRunner.php" "line" => 35 "function" => "handle" "class" => "Symfony\Component\HttpKernel\Kernel" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/autoload_runtime.php" "line" => 29 "function" => "run" "class" => "Symfony\Component\Runtime\Runner\Symfony\HttpKernelRunner" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/public/index.php" "line" => 5 "args" => [ "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/autoload_runtime.php" ] "function" => "require_once" ]]
Symfony\Component\HttpKernel\DataCollector\RequestDataCollector:73 Show trace [[ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/DataCollector/RequestDataCollector.php" "line" => 73 "function" => "getFlashBag" "class" => "Symfony\Component\HttpFoundation\Session\Session" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/Profiler/Profiler.php" "line" => 169 "function" => "collect" "class" => "Symfony\Component\HttpKernel\DataCollector\RequestDataCollector" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/EventListener/ProfilerListener.php" "line" => 108 "function" => "collect" "class" => "Symfony\Component\HttpKernel\Profiler\Profiler" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/event-dispatcher/Debug/WrappedListener.php" "line" => 116 "function" => "onKernelResponse" "class" => "Symfony\Component\HttpKernel\EventListener\ProfilerListener" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/event-dispatcher/EventDispatcher.php" "line" => 220 "function" => "__invoke" "class" => "Symfony\Component\EventDispatcher\Debug\WrappedListener" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/event-dispatcher/EventDispatcher.php" "line" => 56 "function" => "callListeners" "class" => "Symfony\Component\EventDispatcher\EventDispatcher" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/event-dispatcher/Debug/TraceableEventDispatcher.php" "line" => 139 "function" => "dispatch" "class" => "Symfony\Component\EventDispatcher\EventDispatcher" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpKernel.php" "line" => 214 "function" => "dispatch" "class" => "Symfony\Component\EventDispatcher\Debug\TraceableEventDispatcher" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpKernel.php" "line" => 202 "function" => "filterResponse" "class" => "Symfony\Component\HttpKernel\HttpKernel" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpKernel.php" "line" => 76 "function" => "handleRaw" "class" => "Symfony\Component\HttpKernel\HttpKernel" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpCache/SubRequestHandler.php" "line" => 86 "function" => "handle" "class" => "Symfony\Component\HttpKernel\HttpKernel" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/Fragment/InlineFragmentRenderer.php" "line" => 78 "function" => "handle" "class" => "Symfony\Component\HttpKernel\HttpCache\SubRequestHandler" "type" => "::" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/Fragment/FragmentHandler.php" "line" => 83 "function" => "render" "class" => "Symfony\Component\HttpKernel\Fragment\InlineFragmentRenderer" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/DependencyInjection/LazyLoadingFragmentHandler.php" "line" => 47 "function" => "render" "class" => "Symfony\Component\HttpKernel\Fragment\FragmentHandler" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/twig-bridge/Extension/HttpKernelRuntime.php" "line" => 44 "function" => "render" "class" => "Symfony\Component\HttpKernel\DependencyInjection\LazyLoadingFragmentHandler" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/var/cache/dev/twig/b9/b9cb140abab7ef4ef8cb398831c75ac0.php" "line" => 84 "function" => "renderFragment" "class" => "Symfony\Bridge\Twig\Extension\HttpKernelRuntime" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/Template.php" "line" => 394 "function" => "doDisplay" "class" => "__TwigTemplate_dc67cdc305f050f0a27ba7ef152f05af" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/Template.php" "line" => 367 "function" => "displayWithErrorHandling" "class" => "Twig\Template" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/var/cache/dev/twig/c3/c336f4e76fc20e4db84e3be131276b68.php" "line" => 52 "function" => "display" "class" => "Twig\Template" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/Template.php" "line" => 394 "function" => "doDisplay" "class" => "__TwigTemplate_3ce0324a396de697d1fad9fabd68df72" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/Template.php" "line" => 367 "function" => "displayWithErrorHandling" "class" => "Twig\Template" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/Template.php" "line" => 379 "function" => "display" "class" => "Twig\Template" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/TemplateWrapper.php" "line" => 38 "function" => "render" "class" => "Twig\Template" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/Environment.php" "line" => 280 "function" => "render" "class" => "Twig\TemplateWrapper" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/framework-bundle/Controller/AbstractController.php" "line" => 448 "function" => "render" "class" => "Twig\Environment" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/framework-bundle/Controller/AbstractController.php" "line" => 453 "function" => "doRenderView" "class" => "Symfony\Bundle\FrameworkBundle\Controller\AbstractController" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/framework-bundle/Controller/AbstractController.php" "line" => 253 "function" => "doRender" "class" => "Symfony\Bundle\FrameworkBundle\Controller\AbstractController" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/src/Controller/ArticleController.php" "line" => 277 "function" => "render" "class" => "Symfony\Bundle\FrameworkBundle\Controller\AbstractController" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpKernel.php" "line" => 181 "function" => "show" "class" => "App\Controller\ArticleController" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpKernel.php" "line" => 76 "function" => "handleRaw" "class" => "Symfony\Component\HttpKernel\HttpKernel" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/Kernel.php" "line" => 197 "function" => "handle" "class" => "Symfony\Component\HttpKernel\HttpKernel" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/runtime/Runner/Symfony/HttpKernelRunner.php" "line" => 35 "function" => "handle" "class" => "Symfony\Component\HttpKernel\Kernel" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/autoload_runtime.php" "line" => 29 "function" => "run" "class" => "Symfony\Component\Runtime\Runner\Symfony\HttpKernelRunner" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/public/index.php" "line" => 5 "args" => [ "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/autoload_runtime.php" ] "function" => "require_once" ]]
Symfony\Component\Security\Core\Authentication\Token\Storage\UsageTrackingTokenStorage:41 Show trace [[ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/security-core/Authentication/Token/Storage/UsageTrackingTokenStorage.php" "line" => 41 "function" => "getMetadataBag" "class" => "Symfony\Component\HttpFoundation\Session\Session" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/twig-bridge/AppVariable.php" "line" => 103 "function" => "getToken" "class" => "Symfony\Component\Security\Core\Authentication\Token\Storage\UsageTrackingTokenStorage" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/Extension/CoreExtension.php" "line" => 1635 "function" => "getUser" "class" => "Symfony\Bridge\Twig\AppVariable" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/var/cache/dev/twig/a4/a456f2f504a18cd81037fa69e543310c.php" "line" => 200 "function" => "twig_get_attribute" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/Template.php" "line" => 394 "function" => "doDisplay" "class" => "__TwigTemplate_824a013e4f3f4a68e03a2d244e765025" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/Template.php" "line" => 367 "function" => "displayWithErrorHandling" "class" => "Twig\Template" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/Template.php" "line" => 379 "function" => "display" "class" => "Twig\Template" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/TemplateWrapper.php" "line" => 38 "function" => "render" "class" => "Twig\Template" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/Environment.php" "line" => 280 "function" => "render" "class" => "Twig\TemplateWrapper" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/framework-bundle/Controller/AbstractController.php" "line" => 448 "function" => "render" "class" => "Twig\Environment" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/framework-bundle/Controller/AbstractController.php" "line" => 453 "function" => "doRenderView" "class" => "Symfony\Bundle\FrameworkBundle\Controller\AbstractController" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/framework-bundle/Controller/AbstractController.php" "line" => 253 "function" => "doRender" "class" => "Symfony\Bundle\FrameworkBundle\Controller\AbstractController" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/src/Controller/AppController.php" "line" => 126 "function" => "render" "class" => "Symfony\Bundle\FrameworkBundle\Controller\AbstractController" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpKernel.php" "line" => 181 "function" => "renderHeader" "class" => "App\Controller\AppController" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpKernel.php" "line" => 76 "function" => "handleRaw" "class" => "Symfony\Component\HttpKernel\HttpKernel" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpCache/SubRequestHandler.php" "line" => 86 "function" => "handle" "class" => "Symfony\Component\HttpKernel\HttpKernel" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/Fragment/InlineFragmentRenderer.php" "line" => 78 "function" => "handle" "class" => "Symfony\Component\HttpKernel\HttpCache\SubRequestHandler" "type" => "::" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/Fragment/FragmentHandler.php" "line" => 83 "function" => "render" "class" => "Symfony\Component\HttpKernel\Fragment\InlineFragmentRenderer" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/DependencyInjection/LazyLoadingFragmentHandler.php" "line" => 47 "function" => "render" "class" => "Symfony\Component\HttpKernel\Fragment\FragmentHandler" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/twig-bridge/Extension/HttpKernelRuntime.php" "line" => 44 "function" => "render" "class" => "Symfony\Component\HttpKernel\DependencyInjection\LazyLoadingFragmentHandler" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/var/cache/dev/twig/b9/b9cb140abab7ef4ef8cb398831c75ac0.php" "line" => 207 "function" => "renderFragment" "class" => "Symfony\Bridge\Twig\Extension\HttpKernelRuntime" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/Template.php" "line" => 171 "function" => "block_header" "class" => "__TwigTemplate_dc67cdc305f050f0a27ba7ef152f05af" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/var/cache/dev/twig/b9/b9cb140abab7ef4ef8cb398831c75ac0.php" "line" => 91 "function" => "displayBlock" "class" => "Twig\Template" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/Template.php" "line" => 394 "function" => "doDisplay" "class" => "__TwigTemplate_dc67cdc305f050f0a27ba7ef152f05af" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/Template.php" "line" => 367 "function" => "displayWithErrorHandling" "class" => "Twig\Template" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/var/cache/dev/twig/c3/c336f4e76fc20e4db84e3be131276b68.php" "line" => 52 "function" => "display" "class" => "Twig\Template" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/Template.php" "line" => 394 "function" => "doDisplay" "class" => "__TwigTemplate_3ce0324a396de697d1fad9fabd68df72" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/Template.php" "line" => 367 "function" => "displayWithErrorHandling" "class" => "Twig\Template" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/Template.php" "line" => 379 "function" => "display" "class" => "Twig\Template" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/TemplateWrapper.php" "line" => 38 "function" => "render" "class" => "Twig\Template" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/Environment.php" "line" => 280 "function" => "render" "class" => "Twig\TemplateWrapper" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/framework-bundle/Controller/AbstractController.php" "line" => 448 "function" => "render" "class" => "Twig\Environment" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/framework-bundle/Controller/AbstractController.php" "line" => 453 "function" => "doRenderView" "class" => "Symfony\Bundle\FrameworkBundle\Controller\AbstractController" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/framework-bundle/Controller/AbstractController.php" "line" => 253 "function" => "doRender" "class" => "Symfony\Bundle\FrameworkBundle\Controller\AbstractController" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/src/Controller/ArticleController.php" "line" => 277 "function" => "render" "class" => "Symfony\Bundle\FrameworkBundle\Controller\AbstractController" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpKernel.php" "line" => 181 "function" => "show" "class" => "App\Controller\ArticleController" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpKernel.php" "line" => 76 "function" => "handleRaw" "class" => "Symfony\Component\HttpKernel\HttpKernel" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/Kernel.php" "line" => 197 "function" => "handle" "class" => "Symfony\Component\HttpKernel\HttpKernel" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/runtime/Runner/Symfony/HttpKernelRunner.php" "line" => 35 "function" => "handle" "class" => "Symfony\Component\HttpKernel\Kernel" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/autoload_runtime.php" "line" => 29 "function" => "run" "class" => "Symfony\Component\Runtime\Runner\Symfony\HttpKernelRunner" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/public/index.php" "line" => 5 "args" => [ "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/autoload_runtime.php" ] "function" => "require_once" ]]

Flashes

No flash messages were created.

Server Parameters

Defined in .env

Key	Value
APP_ENV	"dev"
APP_SECRET	"0a988e63f011514eaabfc650b599af4d"
CORS_ALLOW_ORIGIN	"*"
DATABASE_URL	"mysql://bbndb_rctuser:33F5W25z40or0f7@localhost:3306/rct_bbntimes"
GOOGLE_RECAPTCHA_SECRET_KEY	"6LdV5fgpAAAAANxzTG8ZMfIjil1wu-1vrQvnUt-x"
GOOGLE_RECAPTCHA_SITE_KEY	"6LdV5fgpAAAAAENKcn73MJAhQrbtQeqgyC4wDLMP"
MAILER_DSN	"smtp://no-reply%40rct.dev.bbntimes.com:Bl6%26gLD48%26Of919@rct.dev.bbntimes.com:465"
MARIADB_PASSWORD	"i!87pK&!85ezc8"

Defined as regular env variables

Key	Value
APP_DEBUG	"1"
BASE	"/public"
CONTEXT_DOCUMENT_ROOT	"/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com"
CONTEXT_PREFIX	""
DOCUMENT_ROOT	"/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com"
FCGI_ROLE	"RESPONDER"
GATEWAY_INTERFACE	"CGI/1.1"
HTTPS	"on"
HTTP_ACCEPT	"/"
HTTP_ACCEPT_ENCODING	"gzip, br, zstd, deflate"
HTTP_CONNECTION	"close"
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CookieController :: renderAnalysis (token = 2b6ecd)

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AppController :: renderHeader (token = f608ab)

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ArticleController :: trendingArticle (token = 194676)

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ArticleController :: relatedArticles (token = 064d8d)

Key	Value
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current_article	App\Entity\Article {#1094-id: 4199 -title: "New Harvard Anticancer Molecule is a Synthetic Biology Breakthrough" -slug: "new-harvard-anticancer-molecule-is-a-synthetic-biology-breakthrough" -introtext: "<p>Over three decades ago, Japanese researchers discovered a naturally occurring chemical in certain types of sea sponges with powerful anticancer properties called halichondrin. Sea sponges are invertebrate animals that lack true tissues and organs; they rely on water flowing through the pores of their spongy bodies to provide nutrients and eliminate waste for survival. In nature, halichondrin occurs in extremely small quantities—blocking the ability for scientists to study, test and develop it into a drug to fight cancer—until now. In a remarkable synthetic biology achievement, Harvard University chemists announced today the creation of synthetic halichondrin, a new anticancer drug candidate called E7130.</p>\r\n" -content: """ \r\n <p>Synthetic biology is a rapidly emerging field of science that includes both the design and formation of entirely new biological systems or components, and the redesign and production of natural biological systems. Synthetic biology is used not only for scientific research purposes, but also to advance genomics, pharmaceuticals, biotechnology, agriculture, materials science, energy, industrial enzymes, biochemicals, biosensing, flavor, and fragrances. In this case, a synthetic version of a naturally occurring chemical in sea sponges was created.</p>\r\n <p>A study published on June 17, 2019 in <em>Scientific Reports</em> led by Harvard Professor Yoshito Kishi along with collaborators from Eisai, a Japanese pharmaceutical company, reports achieving the total synthesis of halichondrin in quantities that will enable anticancer drug discovery and development. The chemists reported successfully producing synthetic halichondrin with over 99.8 percent purity, under good manufacturing conditions, on an over 10-gram scale—a sufficient quantity for clinical studies.</p>\r\n <p>According to the study, halichondrins have shown powerful antitumor abilities in mice studies that were <em>in vivo</em>, and “excellent i<em>n vitro</em> activities towards a variety of human cancer cell types” in various other scientific studies. Yet halichondrins have not been researched in human anticancer research in the past due to the challenges in isolating it in sufficient quantities from sea sponges, or artificially recreating it in a lab. Now this barrier is lifted with the creation of a synthetic halichondrin, E7130.</p>\r\n <p>This achievement was a daunting challenge. According to a report released today in The Harvard Gazette, E7130 is “particularly challenging to replicate because it has 31 chiral centers, asymmetrical points that must each be correctly oriented,” and that there are “roughly 4 billion ways to get it wrong.”</p>\r\n <p>The researchers wrote, “E7130 exhibited potent antiproliferative activities against several cancer cell lines in vitro,” and that it “exerted significant and dose-dependent” antitumor activities with tumor regression in “KPL-4 HER2-positive breast cancer and OSC-19 squamous cell carcinoma of the head and neck.”</p>\r\n <p>E7130 is described by the chemists in the study as “a novel microtubule dynamics inhibitor” that “can also increase intra-tumoral “CD31-positive endothelial cells and reduce α-SMA-positive cancer-associated fibroblasts at pharmacologically relevant compound concentrations.”</p>\r\n <p>The researchers are focused studying E7130 as a potential monotherapy for rare cancers to test the hypothesis that it will be highly effective in fighting cancers where there are many cancer-associated fibroblasts (CAF). The new molecule E7130 is currently in a Japanese Phase I clinical trial. Eisai has a license agreement with Harvard's Office of Technology Development (OTD), and has aspirations to initiate a second clinical trial in the United States in the future.</p>\r\n <p><strong><em>Copyright © 2019 Cami Rosso All rights reserved.</em></strong></p>\r\n <h2><span style="color: #10228b;"><strong>References</strong></span></h2>\r\n <p><span style="color: #000000;">Rosso, Cami. “Synthetic Biology — Life Redesigned.” <em>Medium</em>. March 2, 2017. Retrieved from <a style="color: #000000;" href="https:<a href=" synthetic-biology-life-redesigned-e96b83fd9648="">//medium.com/@camirosso/synthetic-biology-life-redesigned-e96b83fd9648</a>.</span></p>\r\n <p><span style="color: #000000;"><a style="color: #000000;" href="mailto://medium.com/@camirosso/synthetic-biology-life-redesigned-e96b83fd9648</a">Kawano, Satoshi, Ito, Ken, Yahata, Kenzo, Kira, Kazunobu, Abe, Takanori, Akagi, Tsuyoshi, Asano, Makoto, Iso, Kentaro, Sato, Yuki, Matsuura, Fumiyoshi, Ohashi, Isao, Matsumoto, Yasunobu, Isomura, Minetaka, Sasaki, Takeo, Fukuyama, Takashi, Miyashita, Yusuke, Kaburagi, Yosuke, Yokoi, Akira, Asano, Osamu, Owa, Takashi, Kishi, Yoshito. “A landmark in drug discovery based on complex natural product synthesis.” <em>Scientific Reports</em>. June 17, 2019.</a></span></p>\r\n <p><span style="color: #000000;"><a style="color: #000000;" href="mailto://medium.com/@camirosso/synthetic-biology-life-redesigned-e96b83fd9648</a">Perry, Caroline. "Chemists’ breakthrough in synthesis advances a potent anti-cancer agent." <em>The Harvard Gazette</em>. June 17, 2019.</a></span></p> """ -user: Proxies\__CG__\App\Entity\User {#1092 …} -createdAt: DateTime @1560867993 {#1145 date: 2019-06-18 14:26:33.0 UTC (+00:00) } -updatedAt: DateTime @1560868373 {#1150 date: 2019-06-18 14:32:53.0 UTC (+00:00) } -deletedAt: null -category: App\Entity\Category {#445 …} -status: "published" -imageCard: Proxies\__CG__\App\Entity\File {#1184 …} -ImageHeader: Proxies\__CG__\App\Entity\File {#1184 …} -featured: false -mainView: false -clicks: 1939 -comments: Doctrine\ORM\PersistentCollection {#1125 …} -reviewed_at: DateTime @1560867989 {#1148 date: 2019-06-18 14:26:29.0 UTC (+00:00) } -metakey: "" -metadesc: "Over three decades ago, Japanese researchers discovered a naturally occurring chemical in certain types of sea sponges with powerful anticancer properties called halichondrin. Sea sponges are invertebrate animals that lack true tissues and organs; they rely on water flowing through the pores of their spongy bodies to provide nutrients and eliminate waste for survival. In nature, halichondrin occurs in extremely small quantities—blocking the ability for scientists to study, test and develop it into a drug to fight cancer—until now. In a remarkable\u{A0}synthetic biology\u{A0}achievement, Harvard University chemists announced today the creation of synthetic halichondrin, a new anticancer drug candidate called E7130." -robots: null -publishedAt: DateTime @1560867989 {#1147 date: 2019-06-18 14:26:29.0 UTC (+00:00) } -canonical: null -superTag: null}

AppController :: renderFooter (token = 0c094f)

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CookieController :: renderCookie (token = 64b558)

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GET https://rct.dev.bbntimes.com/science/new-harvard-anticancer-molecule-is-a-synthetic-biology-breakthrough

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Sub Requests 6

CookieController :: renderAnalysis (token = 2b6ecd)

AppController :: renderHeader (token = f608ab)

ArticleController :: trendingArticle (token = 194676)

ArticleController :: relatedArticles (token = 064d8d)

AppController :: renderFooter (token = 0c094f)

CookieController :: renderCookie (token = 64b558)