GET https://rct.dev.bbntimes.com/science/deep-learning-is-crucial-in-drug-discovery

Response
200 OK
IP
3.16.66.34
Profiled on
Token
49e718

ArticleController :: show

Request

GET Parameters

None

POST Parameters

None

Uploaded Files

None

Request Attributes

Key Value
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"deep-learning-is-crucial-in-drug-discovery"

Request Headers

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accept 
"*/*"
accept-encoding 
"gzip, br, zstd, deflate"
connection 
"close"
cookie 
"care_did=cbf139ca-6318-4eca-a2f3-a14a34d8244a; laikanxia_google_v=2; laikanxia_cookie_id=250222162956461; PHPSESSID=smvgif1agm0v1bb34cnrpqemo0"
host 
"rct.dev.bbntimes.com"
user-agent 
"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)"
x-php-ob-level 
"1"

Request Content

Request content not available (it was retrieved as a resource).

Response

Response Headers

Header Value
cache-control 
"no-cache, private"
content-type 
"text/html; charset=UTF-8"
date 
"Sat, 22 Feb 2025 08:30:22 GMT"
link 
"</build/runtime.js>; rel="preload"; as="script",</build/644.js>; rel="preload"; as="script",</build/502.js>; rel="preload"; as="script",</build/app.js>; rel="preload"; as="script",</build/view-more.js>; rel="preload"; as="script",</build/term-condition.js>; rel="preload"; as="script",</build/contact.js>; rel="preload"; as="script",</build/scroll-infinite-article.js>; rel="preload"; as="script",</build/app.css>; rel="preload"; as="style",</build/cookie-style.css>; rel="preload"; as="style",</build/term-condition-css.css>; rel="preload"; as="style",</build/contact-css.css>; rel="preload"; as="style",</build/comment-css.css>; rel="preload"; as="style""
x-debug-token 
"49e718"

Cookies

Request Cookies

Key Value
PHPSESSID 
"smvgif1agm0v1bb34cnrpqemo0"
care_did 
"cbf139ca-6318-4eca-a2f3-a14a34d8244a"
laikanxia_cookie_id 
"250222162956461"
laikanxia_google_v 
"2"

Response Cookies

No response cookies

Session 6

Session Metadata

Key Value
Created 
"Sat, 22 Feb 25 08:29:54 +0000"
Last used 
"Sat, 22 Feb 25 08:30:21 +0000"
Lifetime 
0

Session Attributes

Attribute Value
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_csrf/https-cookie_accept 
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Session Usage

6 Usages
Stateless check enabled
Usage
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Symfony\Component\Security\Csrf\TokenStorage\SessionTokenStorage:79
Show trace 
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Symfony\Component\Security\Csrf\TokenStorage\SessionTokenStorage:52
Show trace 
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Symfony\Component\Security\Csrf\TokenStorage\SessionTokenStorage:56
Show trace 
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    "function" => "createView"
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    "line" => 181
    "function" => "show"
    "class" => "App\Controller\ArticleController"
    "type" => "->"
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    "function" => "handleRaw"
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    "line" => 197
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    "class" => "Symfony\Component\HttpKernel\HttpKernel"
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  [
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    "function" => "run"
    "class" => "Symfony\Component\Runtime\Runner\Symfony\HttpKernelRunner"
    "type" => "->"
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      "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/autoload_runtime.php"
    ]
    "function" => "require_once"
  ]
]
Symfony\Component\Security\Core\Authentication\Token\Storage\UsageTrackingTokenStorage:41
Show trace 
[
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/security-core/Authentication/Token/Storage/UsageTrackingTokenStorage.php"
    "line" => 41
    "function" => "getMetadataBag"
    "class" => "Symfony\Component\HttpFoundation\Session\Session"
    "type" => "->"
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    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/twig-bridge/AppVariable.php"
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    "function" => "twig_get_attribute"
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      "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/autoload_runtime.php"
    ]
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]
Symfony\Component\Security\Http\Firewall\ContextListener:171
Show trace 
[
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/security-http/Firewall/ContextListener.php"
    "line" => 171
    "function" => "remove"
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    "function" => "onKernelResponse"
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    "function" => "__invoke"
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    "function" => "callListeners"
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    "function" => "filterResponse"
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Flashes

Flashes

No flash messages were created.

Server Parameters

Server Parameters

Defined in .env

Key Value
APP_ENV 
"dev"
APP_SECRET 
"0a988e63f011514eaabfc650b599af4d"
CORS_ALLOW_ORIGIN 
"*"
DATABASE_URL 
"mysql://bbndb_rctuser:33F5W25z40or0f7@localhost:3306/rct_bbntimes"
GOOGLE_RECAPTCHA_SECRET_KEY 
"6LdV5fgpAAAAANxzTG8ZMfIjil1wu-1vrQvnUt-x"
GOOGLE_RECAPTCHA_SITE_KEY 
"6LdV5fgpAAAAAENKcn73MJAhQrbtQeqgyC4wDLMP"
MAILER_DSN 
"smtp://no-reply%40rct.dev.bbntimes.com:Bl6%26gLD48%26Of919@rct.dev.bbntimes.com:465"
MARIADB_PASSWORD 
"i!87pK&!85ezc8"

Defined as regular env variables

Key Value
APP_DEBUG 
"1"
BASE 
"/public"
CONTEXT_DOCUMENT_ROOT 
"/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com"
CONTEXT_PREFIX 
""
DOCUMENT_ROOT 
"/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com"
FCGI_ROLE 
"RESPONDER"
GATEWAY_INTERFACE 
"CGI/1.1"
HTTPS 
"on"
HTTP_ACCEPT 
"*/*"
HTTP_ACCEPT_ENCODING 
"gzip, br, zstd, deflate"
HTTP_CONNECTION 
"close"
HTTP_COOKIE 
"care_did=cbf139ca-6318-4eca-a2f3-a14a34d8244a; laikanxia_google_v=2; laikanxia_cookie_id=250222162956461; PHPSESSID=smvgif1agm0v1bb34cnrpqemo0"
HTTP_HOST 
"rct.dev.bbntimes.com"
HTTP_USER_AGENT 
"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)"
PASSENGER_COMPILE_NATIVE_SUPPORT_BINARY 
"0"
PASSENGER_DOWNLOAD_NATIVE_SUPPORT_BINARY 
"0"
PATH 
"/usr/local/sbin:/usr/local/bin:/usr/sbin:/usr/bin:/sbin:/bin:/snap/bin"
PHP_SELF 
"/public/index.php"
PP_CUSTOM_PHP_CGI_INDEX 
"plesk-php81-fastcgi"
PP_CUSTOM_PHP_INI 
"/var/www/vhosts/system/rct.dev.bbntimes.com/etc/php.ini"
QUERY_STRING 
""
REDIRECT_BASE 
"/public"
REDIRECT_HTTPS 
"on"
REDIRECT_PASSENGER_COMPILE_NATIVE_SUPPORT_BINARY 
"0"
REDIRECT_PASSENGER_DOWNLOAD_NATIVE_SUPPORT_BINARY 
"0"
REDIRECT_REDIRECT_HTTPS 
"on"
REDIRECT_REDIRECT_PASSENGER_COMPILE_NATIVE_SUPPORT_BINARY 
"0"
REDIRECT_REDIRECT_PASSENGER_DOWNLOAD_NATIVE_SUPPORT_BINARY 
"0"
REDIRECT_REDIRECT_SCRIPT_URI 
"https://rct.dev.bbntimes.com/science/deep-learning-is-crucial-in-drug-discovery"
REDIRECT_REDIRECT_SCRIPT_URL 
"/science/deep-learning-is-crucial-in-drug-discovery"
REDIRECT_REDIRECT_SSL_TLS_SNI 
"rct.dev.bbntimes.com"
REDIRECT_REDIRECT_STATUS 
"200"
REDIRECT_REDIRECT_UNIQUE_ID 
"Z7mLHpDyWLT8YV1VjBo11QAAAIw"
REDIRECT_SCRIPT_URI 
"https://rct.dev.bbntimes.com/science/deep-learning-is-crucial-in-drug-discovery"
REDIRECT_SCRIPT_URL 
"/science/deep-learning-is-crucial-in-drug-discovery"
REDIRECT_SSL_TLS_SNI 
"rct.dev.bbntimes.com"
REDIRECT_STATUS 
"200"
REDIRECT_UNIQUE_ID 
"Z7mLHpDyWLT8YV1VjBo11QAAAIw"
REDIRECT_URL 
"/public/science/deep-learning-is-crucial-in-drug-discovery"
REMOTE_ADDR 
"3.16.66.34"
REMOTE_PORT 
"39049"
REQUEST_METHOD 
"GET"
REQUEST_SCHEME 
"https"
REQUEST_TIME 
1740213022
REQUEST_TIME_FLOAT 
1740213022.1447
REQUEST_URI 
"/science/deep-learning-is-crucial-in-drug-discovery"
SCRIPT_FILENAME 
"/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/public/index.php"
SCRIPT_NAME 
"/public/index.php"
SCRIPT_URI 
"https://rct.dev.bbntimes.com/science/deep-learning-is-crucial-in-drug-discovery"
SCRIPT_URL 
"/science/deep-learning-is-crucial-in-drug-discovery"
SERVER_ADDR 
"5.196.1.209"
SERVER_ADMIN 
"[no address given]"
SERVER_NAME 
"rct.dev.bbntimes.com"
SERVER_PORT 
"443"
SERVER_PROTOCOL 
"HTTP/1.1"
SERVER_SIGNATURE 
"<address>Apache Server at rct.dev.bbntimes.com Port 443</address>\n"
SERVER_SOFTWARE 
"Apache"
SSL_TLS_SNI 
"rct.dev.bbntimes.com"
SYMFONY_DOTENV_VARS 
"APP_ENV,APP_SECRET,DATABASE_URL,MARIADB_PASSWORD,CORS_ALLOW_ORIGIN,MAILER_DSN,GOOGLE_RECAPTCHA_SECRET_KEY,GOOGLE_RECAPTCHA_SITE_KEY"
UNIQUE_ID 
"Z7mLHpDyWLT8YV1VjBo11QAAAIw"

Sub Requests 6

CookieController :: renderAnalysis (token = 5539d3)

Key Value
_controller 
"App\Controller\CookieController::renderAnalysis"
_format 
"html"
_locale 
"en"
_stopwatch_token 
"fe4030"

AppController :: renderHeader (token = 2be613)

Key Value
_controller 
"App\Controller\AppController::renderHeader"
_format 
"html"
_locale 
"en"
_stopwatch_token 
"e2a9e9"
slug 
"home"

ArticleController :: trendingArticle (token = 24df30)

Key Value
_controller 
"App\Controller\ArticleController::trendingArticle"
_format 
"html"
_locale 
"en"
_stopwatch_token 
"3d44f0"
category 
"Science"

ArticleController :: relatedArticles (token = ab551f)

Key Value
_controller 
"App\Controller\ArticleController::relatedArticles"
_format 
"html"
_locale 
"en"
_stopwatch_token 
"e9eff0"
current_article 
App\Entity\Article {#1094
  -id: 12985
  -title: "Deep Learning is Crucial in Drug Discovery"
  -slug: "deep-learning-is-crucial-in-drug-discovery"
  -introtext: "<p>Deep learning is promising for solving a variety of issues in the pharmaceutical industry.</p>\r\n"
  -content: """
    \r\n
    <p class="text-muted">A few decades ago, the process of finding new drugs and developing them was confined to a group of medicinal chemists working in a lab. To get one medicine approved for use, there would be a significant investment of time and money in testing, validation, and synthesis methods. The development of numerous bioinformatics, pharmacy informatics, and cheminformatics tools has assisted in the acceleration of the drug discovery process due to advances in computational approaches mixed with an explosion in deep learning techniques.</p>\r\n
    <p>Deep learning assists in the global initiative to curb the spread of infectious diseases and substantially speeds up drug discovery. Deep learning can quickly and accurately find drug candidates for novel, widespread diseases, improving the efficiency of screening antimicrobial compounds against a wide range of bacteria.</p>\r\n
    <p>Drug discovery using deep learning&nbsp;allows for sophisticated image interpretation, molecular structure, function prediction, and the automated creation of novel chemical entities with specific features. Despite the increasing number of promising future applications, the underlying mathematical models are often challenging for the human mind to comprehend. To answer the requirement for a new narrative of the machine language of the molecular sciences, there is a desire for "explainable" deep learning approaches.</p>\r\n
    <h1>Deep Learning Tools for Drug Discovery</h1>\r\n
    <p>Software engineers and pharmacists have collaborated to build DL-based tools, predictive analytics and algorithms that may be utilized in the drug research and development procedure to harness the tremendous potential of deep learning models. Deep learning tools are classified based on their functionality as follows:</p>\r\n
    <p><img src="/images/DEEP_LEARNING_TOOLS_FOR_DRUG_DISCOVERY.png" alt="DEEP_LEARNING_TOOLS_FOR_DRUG_DISCOVERY.png" width="1003" height="1000" /></p>\r\n
    <h3>1. Prediction of Binding Affinity and Drug-Target Interactions</h3>\r\n
    <p>A significant gap exists between known and unknown drug-target pairs due to the restricted and inadequate knowledge about drug-target interactions based on laboratory studies, which has prompted attention in the quest for effective approaches to&nbsp;drug-target interactions (DTI) prediction.</p>\r\n
    <p>Conventional means of DTI prediction have been hampered by financial and technological issues, but deep learning approaches are achieving the same results more efficiently.</p>\r\n
    <p>Currently, ligand-based approaches, chemo-genomic approaches, text mining techniques, ML/ DL-based techniques and network-based strategies are the main computational methods employed in DTI prediction. Some examples of deep learning models in drug discovery for the prediction of DTI and binding affinity are DTI-CNN, DeepCPI, DeepDTA, Deep docking, etc.</p>\r\n
    <h3>2. Protein Structure Prediction</h3>\r\n
    <p>Protein structure identification demands time and complex experimental techniques like X-ray crystallography, NMR spectroscopy, electron microscopy, etc. Competent computational methods are required to fill the vacuum left by many unidentified protein structures, which allows structural bioinformatics on a wide scale. Scientists are now deploying DL approaches that can confidently predict protein structure to make the process considerably simpler and less time-consuming. Alphafold and CASP are two of the most popular deep learning models used for this purpose.</p>\r\n
    <h3>3. Generation of Novel Molecules</h3>\r\n
    <p>Certain DL algorithms seek to identify novel drugs and drug-like substances. Modern deep learning models emphasize the compounds' capacity to be synthesized and drug-like qualities, as opposed to earlier software tools, which sought to discover fresh compounds with a limited chemical appeal and diversity.</p>\r\n
    <h3>4.&nbsp; Hit Identification using Virtual Screening</h3>\r\n
    <p>With the help of virtual screening, it is possible to scan through enormous databases of small molecules and find hits that are more likely to bind to therapeutic targets. Distinct characteristics of a chemical substance and the target are used in the virtual screening technique. Numerous studies have demonstrated that DL algorithms, such as Similarity Search and DeepVS, perform substantially better in virtual screening than other ML algorithms, particularly when used in the de novo molecular design process, which uses sequential data to create molecules with the required characteristics.</p>\r\n
    <h3>5. Drug Activity Prediction</h3>\r\n
    <p>The molecular attributes of drug compounds can be diagnosed using DL algorithms, which also estimate the behavior of known molecules, including their bodily mechanisms. The cost and time required will be greatly reduced by applying the semi-supervised learning technique to anticipate the therapeutic application of pharmaceuticals from their structural formulas. Due to its logical data adjustment and small number of labeled data, Multicon is a DL-based tool with a higher rate of drug activity estimation than other semi-supervised learning algorithms.</p>\r\n
    <h1>Future of Drug Discovey Using Deep Learning</h1>\r\n
    <p>A long and costly process,&nbsp;drug discovery&nbsp;has always faced challenges in moving a drug prospect into clinical testing. Deep learning has significantly enhanced the operation's success rate, which minimizes the overall research cost. With the massive advancements in the DL toolset, it can yield considerable benefits. Modern DL techniques will certainly be highly valued in the upcoming era of big data search and analysis for drug design and discovery after considering the recent success of such methodology and its use by pharmaceutical corporations.</p>
    """
  -user: Proxies\__CG__\App\Entity\User {#1092 …}
  -createdAt: DateTime @1668610474 {#1145
    date: 2022-11-16 14:54:34.0 UTC (+00:00)
  }
  -updatedAt: DateTime @1668610642 {#1150
    date: 2022-11-16 14:57:22.0 UTC (+00:00)
  }
  -deletedAt: null
  -category: App\Entity\Category {#445 …}
  -status: "published"
  -imageCard: Proxies\__CG__\App\Entity\File {#1184 …}
  -ImageHeader: Proxies\__CG__\App\Entity\File {#1184 …}
  -featured: false
  -mainView: false
  -clicks: 3787
  -comments: Doctrine\ORM\PersistentCollection {#1125 …}
  -reviewed_at: DateTime @1668610474 {#1148
    date: 2022-11-16 14:54:34.0 UTC (+00:00)
  }
  -metakey: "Deep Learning is Crucial in Drug Discovery"
  -metadesc: "Deep learning is promising for solving a variety of issues in the pharmaceutical industry."
  -robots: null
  -publishedAt: DateTime @1668610474 {#1147
    date: 2022-11-16 14:54:34.0 UTC (+00:00)
  }
  -canonical: null
  -superTag: null
}

AppController :: renderFooter (token = 6ec395)

Key Value
_controller 
"App\Controller\AppController::renderFooter"
_format 
"html"
_locale 
"en"
_stopwatch_token 
"c0445a"

CookieController :: renderCookie (token = eabab6)

Key Value
_controller 
"App\Controller\CookieController::renderCookie"
_format 
"html"
_locale 
"en"
_stopwatch_token 
"ab4140"