GET https://rct.dev.bbntimes.com/science/when-safe-drugs-become-risky-the-clinical-danger-zone

Response
200 OK
IP
3.15.193.134
Profiled on
Token
51edbc

ArticleController :: show

Request

GET Parameters

None

POST Parameters

None

Uploaded Files

None

Request Attributes

Key Value
_controller 
"App\Controller\ArticleController::show"
_firewall_context 
"security.firewall.map.context.main"
_links 
Symfony\Component\WebLink\GenericLinkProvider {#3649
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      -attributes: [
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    }
    3766 => Symfony\Component\WebLink\Link {#3766
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      -attributes: [
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      ]
    }
    3763 => Symfony\Component\WebLink\Link {#3763
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      -rel: [
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      ]
      -attributes: [
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      ]
    }
    3762 => Symfony\Component\WebLink\Link {#3762
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      -rel: [
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      -attributes: [
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      ]
    }
    3761 => Symfony\Component\WebLink\Link {#3761
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    }
    3760 => Symfony\Component\WebLink\Link {#3760
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      -rel: [
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      ]
      -attributes: [
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      ]
    }
    3759 => Symfony\Component\WebLink\Link {#3759
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      -rel: [
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      -attributes: [
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    }
    3758 => Symfony\Component\WebLink\Link {#3758
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      -attributes: [
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    }
    3757 => Symfony\Component\WebLink\Link {#3757
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      -rel: [
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      -attributes: [
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}
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"article_show"
_route_params 
[
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]
_security_firewall_run 
"_security_main"
_stopwatch_token 
"ee67f0"
category 
"science"
slug 
"when-safe-drugs-become-risky-the-clinical-danger-zone"

Request Headers

Header Value
accept 
"*/*"
accept-encoding 
"gzip, br, zstd, deflate"
connection 
"close"
cookie 
"PHPSESSID=qtfi2ekh59lsj81t2anovm7596"
host 
"rct.dev.bbntimes.com"
user-agent 
"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)"
x-php-ob-level 
"1"

Request Content

Request content not available (it was retrieved as a resource).

Response

Response Headers

Header Value
cache-control 
"no-cache, private"
content-type 
"text/html; charset=UTF-8"
date 
"Wed, 16 Apr 2025 06:51:35 GMT"
link 
"</build/runtime.js>; rel="preload"; as="script",</build/644.js>; rel="preload"; as="script",</build/502.js>; rel="preload"; as="script",</build/app.js>; rel="preload"; as="script",</build/view-more.js>; rel="preload"; as="script",</build/term-condition.js>; rel="preload"; as="script",</build/contact.js>; rel="preload"; as="script",</build/scroll-infinite-article.js>; rel="preload"; as="script",</build/app.css>; rel="preload"; as="style",</build/cookie-style.css>; rel="preload"; as="style",</build/term-condition-css.css>; rel="preload"; as="style",</build/contact-css.css>; rel="preload"; as="style",</build/comment-css.css>; rel="preload"; as="style""
x-debug-token 
"51edbc"

Cookies

Request Cookies

Key Value
PHPSESSID 
"qtfi2ekh59lsj81t2anovm7596"

Response Cookies

No response cookies

Session 6

Session Metadata

Key Value
Created 
"Wed, 16 Apr 25 06:49:57 +0000"
Last used 
"Wed, 16 Apr 25 06:51:33 +0000"
Lifetime 
0

Session Attributes

Attribute Value
_csrf/https-comment 
"pyGforn3DbHkHJmQkXNXU_JQ-wUKScq79fHannLYI7I"
_csrf/https-cookie_accept 
"OaBsOWZyLjf_Yptx2Y7VMgCzpvb_HL9CJ9_gX9P9Ekk"

Session Usage

6 Usages
Stateless check enabled
Usage
Symfony\Component\Security\Csrf\TokenStorage\SessionTokenStorage:76
Show trace 
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Symfony\Component\Security\Csrf\TokenStorage\SessionTokenStorage:79
Show trace 
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Symfony\Component\Security\Csrf\TokenStorage\SessionTokenStorage:52
Show trace 
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Symfony\Component\Security\Csrf\TokenStorage\SessionTokenStorage:56
Show trace 
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    "function" => "run"
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    ]
    "function" => "require_once"
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]
Symfony\Component\Security\Core\Authentication\Token\Storage\UsageTrackingTokenStorage:41
Show trace 
[
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/security-core/Authentication/Token/Storage/UsageTrackingTokenStorage.php"
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    "function" => "getMetadataBag"
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]
Symfony\Component\Security\Http\Firewall\ContextListener:171
Show trace 
[
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/security-http/Firewall/ContextListener.php"
    "line" => 171
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    "function" => "__invoke"
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Flashes

Flashes

No flash messages were created.

Server Parameters

Server Parameters

Defined in .env

Key Value
APP_ENV 
"dev"
APP_SECRET 
"0a988e63f011514eaabfc650b599af4d"
CORS_ALLOW_ORIGIN 
"*"
DATABASE_URL 
"mysql://bbndb_rctuser:33F5W25z40or0f7@localhost:3306/rct_bbntimes"
GOOGLE_RECAPTCHA_SECRET_KEY 
"6LdV5fgpAAAAANxzTG8ZMfIjil1wu-1vrQvnUt-x"
GOOGLE_RECAPTCHA_SITE_KEY 
"6LdV5fgpAAAAAENKcn73MJAhQrbtQeqgyC4wDLMP"
MAILER_DSN 
"smtp://no-reply%40rct.dev.bbntimes.com:Bl6%26gLD48%26Of919@rct.dev.bbntimes.com:465"
MARIADB_PASSWORD 
"i!87pK&!85ezc8"

Defined as regular env variables

Key Value
APP_DEBUG 
"1"
BASE 
"/public"
CONTEXT_DOCUMENT_ROOT 
"/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com"
CONTEXT_PREFIX 
""
DOCUMENT_ROOT 
"/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com"
FCGI_ROLE 
"RESPONDER"
GATEWAY_INTERFACE 
"CGI/1.1"
HTTPS 
"on"
HTTP_ACCEPT 
"*/*"
HTTP_ACCEPT_ENCODING 
"gzip, br, zstd, deflate"
HTTP_CONNECTION 
"close"
HTTP_COOKIE 
"PHPSESSID=qtfi2ekh59lsj81t2anovm7596"
HTTP_HOST 
"rct.dev.bbntimes.com"
HTTP_USER_AGENT 
"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)"
PASSENGER_COMPILE_NATIVE_SUPPORT_BINARY 
"0"
PASSENGER_DOWNLOAD_NATIVE_SUPPORT_BINARY 
"0"
PATH 
"/usr/local/sbin:/usr/local/bin:/usr/sbin:/usr/bin:/sbin:/bin:/snap/bin"
PHP_SELF 
"/public/index.php"
PP_CUSTOM_PHP_CGI_INDEX 
"plesk-php81-fastcgi"
PP_CUSTOM_PHP_INI 
"/var/www/vhosts/system/rct.dev.bbntimes.com/etc/php.ini"
QUERY_STRING 
""
REDIRECT_BASE 
"/public"
REDIRECT_HTTPS 
"on"
REDIRECT_PASSENGER_COMPILE_NATIVE_SUPPORT_BINARY 
"0"
REDIRECT_PASSENGER_DOWNLOAD_NATIVE_SUPPORT_BINARY 
"0"
REDIRECT_REDIRECT_HTTPS 
"on"
REDIRECT_REDIRECT_PASSENGER_COMPILE_NATIVE_SUPPORT_BINARY 
"0"
REDIRECT_REDIRECT_PASSENGER_DOWNLOAD_NATIVE_SUPPORT_BINARY 
"0"
REDIRECT_REDIRECT_SCRIPT_URI 
"https://rct.dev.bbntimes.com/science/when-safe-drugs-become-risky-the-clinical-danger-zone"
REDIRECT_REDIRECT_SCRIPT_URL 
"/science/when-safe-drugs-become-risky-the-clinical-danger-zone"
REDIRECT_REDIRECT_SSL_TLS_SNI 
"rct.dev.bbntimes.com"
REDIRECT_REDIRECT_STATUS 
"200"
REDIRECT_REDIRECT_UNIQUE_ID 
"Z_9TdmoKrZxLoz1OR4RzkwAAAIg"
REDIRECT_SCRIPT_URI 
"https://rct.dev.bbntimes.com/science/when-safe-drugs-become-risky-the-clinical-danger-zone"
REDIRECT_SCRIPT_URL 
"/science/when-safe-drugs-become-risky-the-clinical-danger-zone"
REDIRECT_SSL_TLS_SNI 
"rct.dev.bbntimes.com"
REDIRECT_STATUS 
"200"
REDIRECT_UNIQUE_ID 
"Z_9TdmoKrZxLoz1OR4RzkwAAAIg"
REDIRECT_URL 
"/public/science/when-safe-drugs-become-risky-the-clinical-danger-zone"
REMOTE_ADDR 
"3.15.193.134"
REMOTE_PORT 
"29710"
REQUEST_METHOD 
"GET"
REQUEST_SCHEME 
"https"
REQUEST_TIME 
1744786294
REQUEST_TIME_FLOAT 
1744786294.6735
REQUEST_URI 
"/science/when-safe-drugs-become-risky-the-clinical-danger-zone"
SCRIPT_FILENAME 
"/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/public/index.php"
SCRIPT_NAME 
"/public/index.php"
SCRIPT_URI 
"https://rct.dev.bbntimes.com/science/when-safe-drugs-become-risky-the-clinical-danger-zone"
SCRIPT_URL 
"/science/when-safe-drugs-become-risky-the-clinical-danger-zone"
SERVER_ADDR 
"5.196.1.209"
SERVER_ADMIN 
"[no address given]"
SERVER_NAME 
"rct.dev.bbntimes.com"
SERVER_PORT 
"443"
SERVER_PROTOCOL 
"HTTP/1.1"
SERVER_SIGNATURE 
"<address>Apache Server at rct.dev.bbntimes.com Port 443</address>\n"
SERVER_SOFTWARE 
"Apache"
SSL_TLS_SNI 
"rct.dev.bbntimes.com"
SYMFONY_DOTENV_VARS 
"APP_ENV,APP_SECRET,DATABASE_URL,MARIADB_PASSWORD,CORS_ALLOW_ORIGIN,MAILER_DSN,GOOGLE_RECAPTCHA_SECRET_KEY,GOOGLE_RECAPTCHA_SITE_KEY"
UNIQUE_ID 
"Z_9TdmoKrZxLoz1OR4RzkwAAAIg"

Sub Requests 6

CookieController :: renderAnalysis (token = 914d82)

Key Value
_controller 
"App\Controller\CookieController::renderAnalysis"
_format 
"html"
_locale 
"en"
_stopwatch_token 
"6f702c"

AppController :: renderHeader (token = dcf2bf)

Key Value
_controller 
"App\Controller\AppController::renderHeader"
_format 
"html"
_locale 
"en"
_stopwatch_token 
"2247f7"
slug 
"home"

ArticleController :: trendingArticle (token = 1ee909)

Key Value
_controller 
"App\Controller\ArticleController::trendingArticle"
_format 
"html"
_locale 
"en"
_stopwatch_token 
"1a4d8f"
category 
"Science"

ArticleController :: relatedArticles (token = 325070)

Key Value
_controller 
"App\Controller\ArticleController::relatedArticles"
_format 
"html"
_locale 
"en"
_stopwatch_token 
"022d5d"
current_article 
App\Entity\Article {#1094
  -id: 3063
  -title: "When Safe Drugs Become Risky: The Clinical Danger Zone"
  -slug: "when-safe-drugs-become-risky-the-clinical-danger-zone"
  -introtext: "<p class="p1"><span class="s1">Each year in the U.S., approximately four billion prescriptions are&nbsp;<a href="https://www.kff.org/health-costs/state-indicator/total-retail-rx-drugs/?currentTimeframe=0&amp;sortModel=%7B%22colId%22:%22Location%22,%22sort%22:%22asc%22%7D"><span class="s2">filled</span></a>. That's a big number. But perhaps an even "bigger" number is the four to eight million of those&nbsp;<a href="https://bpspubs.onlinelibrary.wiley.com/doi/epdf/10.1111/j.1365-2125.2009.03418.x"><span class="s2">dispensed</span></a>&nbsp;that will potentially involve life-threatening errors. Going to the pharmacy for a necessary medicine is not supposed to be a high-stakes game. But, even physicians and the nation’s most trusted profession -- pharmacists -- aren’t infallible. Generally, it’s not their fault. What goes wrong?</span></p>\r\n"
  -content: """
    \r\n
    <p class="p1"><span class="s1">Prescription errors take place within EHR-based prescribing environments: sometimes referred to as “the typos that can kill.” They range from selecting the wrong prescription, to the wrong dose or the wrong patient recipient. Yet despite the innocent reasons, these errors can result in tragedy, and often result in unspeakable harm. But they are only part of a larger problem.</span></p>\r\n
    <p class="p1"><span class="s1">Each person is unique, and each person may have a different reaction to the same drug. Adverse drug effects (ADEs) present with the changing clinical statuses of patients. ADEs -- more than sixty percent of medication-related problems--can take place any time during the course of treatment and are usually under diagnosed or diagnosed too late. Hints, clues and aggravating factors are, in many occasions missed by providers, exposing patients to potential harm.</span></p>\r\n
    <p class="p1"><span class="s1">When a patient’s clinical status changes -- and this is the key point -- a previously safe medication may become dangerous. This exposes patients to unexpected events that can be anything from a nuisance to life-threatening. Patients and providers are left completely exposed to these unwanted outlier risks.&nbsp; And it's a simple reality that clinical status is far from the fixed reality that exists at the time of prescribing a drug.</span></p>\r\n
    <p class="p1"><span class="s1">There is a potential safety net.</span></p>\r\n
    <p class="p1"><span class="s1">Drawing upon technology used in financial services that monitors credit card purchases,&nbsp;<a href="http://www.medaware.com/"><span class="s2">MedAware</span></a>, is using an artificial intelligence (AI)-based technology that draws upon the outlier detection system that keeps your wallet safe. Rather than working with pre-assigned rules, MedAware AI learns the prescribing patterns of the physician, institution and patient. It generates models of normal prescribing patterns to find the outlier prescriptions that could be dangerous errors or could lead to ADEs.&nbsp; It's a needle in the haystack system that keeps people safe much like credit card companies send you alerts for unusual purchase patterns.</span></p>\r\n
    <p class="p1"><span class="s1">Urgency and collaboration save lives.&nbsp; Rather than find out about an error in the ER, when it might be too late,&nbsp;<a href="http://www.medaware.com/"><span class="s2">MedAware</span></a>&nbsp;provides a system that taps into the physician’s workflow via the EMR. After all, with time sensitive medication-related errors, there is the danger of falling into the “medical danger zone,” -- the gap between an error realized and an action taken by the physician is time sensitive. The MedAware system enables the doctor to engage and correct.</span></p>\r\n
    <p class="p1"><span class="s1">MedAware’s technology acts as a protective layer above EMRs and clinical decision support tools. When a prescription outlier is detected, physicians receive notification within the electronic prescribing environment. The “typos” are either caught at the point of care -- when the patient is still with the prescriber and updated on the spot. Or the error is addressed following a change in the patient’s clinical record (i.e. new lab result or vital sign), after the prescription was entered. These alerts are displayed as a physician’s task, within the physician’s workflow and the EMR user interface. This enables the prescriber to protect the patient from an evolving ADE even after they’ve left for home.</span></p>\r\n
    <p class="p1"><span class="s1">In recent results&nbsp;<a href="https://medcitynews.com/2018/09/medaware-sheba-medical-center/"><span class="s2">reported</span></a>&nbsp;in a live clinical implementation at Sheba Medical Center in Israel, a 1,900 bed and one of the country’s largest medical centers, MedAware notifications were 80% on time and on target. While understanding the importance of avoiding the medical danger zone is a given, physicians, seeing the immediate benefits to their patients, are paying attention to MedAware notifications.</span></p>\r\n
    <p class="p1"><span class="s1">When it comes to ADE risk, there is little alert fatigue. Every doctor and every patient appreciates having a little added intel -- even if it is artificial intelligence -- looking over their shoulder and out for their mutual best interest. When MedAware sends an alert, physicians were shown to revisit and change their prescriptions in a majority of cases -- here’s a case where med/tech is improving care, protecting patients and eliminating unnecessary risk.</span></p>\r\n
    <p class="p2"><span class="s1">Score one for technology.</span></p>\r\n
    <p class="p2"><span class="s1"><i>A version of this article first appeared on <a href="https://www.forbes.com/sites/johnnosta/2018/11/05/when-safe-drugs-become-risky-the-clinical-danger-zone/" target="_blank" rel="noopener">Forbes</a>.</i></span></p>\r\n
    <p class="p5"><span class="s1">I am the Founder of NOSTALAB -- a leading digital health think tank providing business and marketing insights to help the life science industry navigate the complex aspects of innovation in the context of exponential change. I help define, dissect and deliberate global trends in digital health as an active participant working with clinicians, innovators and patients.</span></p>\r\n
    <p class="p2"><span class="s1"><i>Follow me&nbsp;</i><a href="https://twitter.com/JohnNosta"><span class="s2"><i>@JohnNosta</i></span></a><i>&nbsp;for an enlightening and unexpected view of the future.</i></span></p>
    """
  -user: Proxies\__CG__\App\Entity\User {#1092 …}
  -createdAt: DateTime @1542795470 {#1145
    date: 2018-11-21 10:17:50.0 UTC (+00:00)
  }
  -updatedAt: DateTime @1542795819 {#1150
    date: 2018-11-21 10:23:39.0 UTC (+00:00)
  }
  -deletedAt: null
  -category: App\Entity\Category {#445 …}
  -status: "published"
  -imageCard: Proxies\__CG__\App\Entity\File {#1184 …}
  -ImageHeader: Proxies\__CG__\App\Entity\File {#1184 …}
  -featured: false
  -mainView: false
  -clicks: 2629
  -comments: Doctrine\ORM\PersistentCollection {#1125 …}
  -reviewed_at: DateTime @1542795467 {#1148
    date: 2018-11-21 10:17:47.0 UTC (+00:00)
  }
  -metakey: ""
  -metadesc: "Each year in the U.S., approximately four billion prescriptions are\u{A0}filled. That's a big number. But perhaps an even "bigger" number is the four to eight million of those\u{A0}dispensed\u{A0}that will potentially involve life-threatening errors. Going to the pharmacy for a necessary medicine is not supposed to be a high-stakes game. But, even physicians and the nation’s most trusted profession -- pharmacists -- aren’t infallible. Generally, it’s not their fault. What goes wrong?"
  -robots: null
  -publishedAt: DateTime @1542795467 {#1147
    date: 2018-11-21 10:17:47.0 UTC (+00:00)
  }
  -canonical: null
  -superTag: null
}

AppController :: renderFooter (token = 0ef2b3)

Key Value
_controller 
"App\Controller\AppController::renderFooter"
_format 
"html"
_locale 
"en"
_stopwatch_token 
"f1fe67"

CookieController :: renderCookie (token = f020fb)

Key Value
_controller 
"App\Controller\CookieController::renderCookie"
_format 
"html"
_locale 
"en"
_stopwatch_token 
"917087"