GET https://rct.dev.bbntimes.com/science/muddled-guidance-at-menopause

ArticleController :: show

Request

GET Parameters

None

POST Parameters

None

Uploaded Files

None

Request Attributes

Key Value
_controller
"App\Controller\ArticleController::show"
_firewall_context
"security.firewall.map.context.main"
_links
Symfony\Component\WebLink\GenericLinkProvider {#3604
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    3723 => Symfony\Component\WebLink\Link {#3723
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    3722 => Symfony\Component\WebLink\Link {#3722
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      -rel: [
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      -attributes: [
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      ]
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    3721 => Symfony\Component\WebLink\Link {#3721
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      -rel: [
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    }
    3720 => Symfony\Component\WebLink\Link {#3720
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      -rel: [
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      -attributes: [
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    }
    3719 => Symfony\Component\WebLink\Link {#3719
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      -rel: [
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      -attributes: [
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      ]
    }
    3718 => Symfony\Component\WebLink\Link {#3718
      -href: "/build/contact.js"
      -rel: [
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      -attributes: [
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      ]
    }
    3717 => Symfony\Component\WebLink\Link {#3717
      -href: "/build/scroll-infinite-article.js"
      -rel: [
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      ]
      -attributes: [
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      ]
    }
    3716 => Symfony\Component\WebLink\Link {#3716
      -href: "/build/app.css"
      -rel: [
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      ]
      -attributes: [
        "as" => "style"
      ]
    }
    3715 => Symfony\Component\WebLink\Link {#3715
      -href: "/build/cookie-style.css"
      -rel: [
        "preload" => "preload"
      ]
      -attributes: [
        "as" => "style"
      ]
    }
    3714 => Symfony\Component\WebLink\Link {#3714
      -href: "/build/term-condition-css.css"
      -rel: [
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      ]
      -attributes: [
        "as" => "style"
      ]
    }
    3713 => Symfony\Component\WebLink\Link {#3713
      -href: "/build/contact-css.css"
      -rel: [
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      -attributes: [
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      ]
    }
    3712 => Symfony\Component\WebLink\Link {#3712
      -href: "/build/comment-css.css"
      -rel: [
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      -attributes: [
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      ]
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}
_route
"article_show"
_route_params
[
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  "slug" => "muddled-guidance-at-menopause"
]
_security_firewall_run
"_security_main"
_stopwatch_token
"4ea023"
category
"science"
slug
"muddled-guidance-at-menopause"

Request Headers

Header Value
accept
"text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7"
accept-encoding
"gzip, deflate, br, zstd"
cache-control
"no-cache"
connection
"close"
host
"rct.dev.bbntimes.com"
pragma
"no-cache"
sec-ch-ua
""Chromium";v="130", "HeadlessChrome";v="130", "Not?A_Brand";v="99""
sec-ch-ua-mobile
"?0"
sec-ch-ua-platform
""Windows""
sec-fetch-dest
"document"
sec-fetch-mode
"navigate"
sec-fetch-site
"none"
sec-fetch-user
"?1"
upgrade-insecure-requests
"1"
user-agent
"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)"
x-php-ob-level
"1"

Request Content

Request content not available (it was retrieved as a resource).

Response

Response Headers

Header Value
cache-control
"no-cache, private"
content-type
"text/html; charset=UTF-8"
date
"Sat, 14 Jun 2025 07:40:36 GMT"
link
"</build/runtime.js>; rel="preload"; as="script",</build/644.js>; rel="preload"; as="script",</build/502.js>; rel="preload"; as="script",</build/app.js>; rel="preload"; as="script",</build/view-more.js>; rel="preload"; as="script",</build/term-condition.js>; rel="preload"; as="script",</build/contact.js>; rel="preload"; as="script",</build/scroll-infinite-article.js>; rel="preload"; as="script",</build/app.css>; rel="preload"; as="style",</build/cookie-style.css>; rel="preload"; as="style",</build/term-condition-css.css>; rel="preload"; as="style",</build/contact-css.css>; rel="preload"; as="style",</build/comment-css.css>; rel="preload"; as="style""
x-debug-token
"d4b203"

Cookies

Request Cookies

No request cookies

Response Cookies

No response cookies

Session 11

Session Metadata

Key Value
Created
"Sat, 14 Jun 25 07:40:35 +0000"
Last used
"Sat, 14 Jun 25 07:40:35 +0000"
Lifetime
0

Session Attributes

Attribute Value
_csrf/https-comment
"xjeTxJYkD5LtQlplKRdrZ0c2tVMaxle4RbNf6hdRXq8"
_csrf/https-cookie_accept
"9fjFXWuzW7kguiDzR0iOt9qFMVqDNHgBCxms9ER9K7Y"

Session Usage

11 Usages
Stateless check enabled
Usage
Symfony\Component\Security\Csrf\TokenStorage\SessionTokenStorage:76
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Symfony\Component\Security\Csrf\TokenStorage\SessionTokenStorage:79
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Server Parameters

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APP_ENV
"dev"
APP_SECRET
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CORS_ALLOW_ORIGIN
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DATABASE_URL
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Defined as regular env variables

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APP_DEBUG
"1"
BASE
"/public"
CONTEXT_DOCUMENT_ROOT
"/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com"
CONTEXT_PREFIX
""
DOCUMENT_ROOT
"/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com"
FCGI_ROLE
"RESPONDER"
GATEWAY_INTERFACE
"CGI/1.1"
HTTPS
"on"
HTTP_ACCEPT
"text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7"
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PASSENGER_DOWNLOAD_NATIVE_SUPPORT_BINARY
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PP_CUSTOM_PHP_INI
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REDIRECT_HTTPS
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"App\Controller\CookieController::renderAnalysis"
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AppController :: renderHeader (token = c3265d)

Key Value
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"App\Controller\AppController::renderHeader"
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"en"
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"dde4de"
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ArticleController :: trendingArticle (token = 14d4f2)

Key Value
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"App\Controller\ArticleController::trendingArticle"
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"html"
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"en"
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"d0298a"
category
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ArticleController :: relatedArticles (token = adde05)

Key Value
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"App\Controller\ArticleController::relatedArticles"
_format
"html"
_locale
"en"
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"d29586"
current_article
App\Entity\Article {#1094
  -id: 1731
  -title: "Muddled Guidance at Menopause"
  -slug: "muddled-guidance-at-menopause"
  -introtext: "<p>By definition, a muddle is an untidy or disorganized collection.&nbsp;The verb denotes propagating confusion by bringing some topic into just such a state.&nbsp;I regret to say that, accordingly, the&nbsp;<a href="https://www.uspreventiveservicestaskforce.org/" target="_blank" rel="nofollow noopener">United States Preventive Services Task Force</a>&nbsp;(USPSTF) is poised to muddle the management of symptoms, and chronic disease risk at menopause.</p>\r\n"
  -content: """
    \r\n
    <p>As I have indicated&nbsp;<a href="https://www.forbes.com/sites/davidkatz/2017/05/22/reprising-the-wrong-verdict-for-hormone-replacement-at-menopause/#7ade96ce7121" target="_blank" rel="nofollow noopener">recently</a>, and repeatedly over the years, I have enormous respect for the USPSTF, an influential panel of independent experts who generate strictly evidence-based guidelines for clinical preventive services, i.e., those medical practices dedicated to the prevention of morbidity and premature mortality.&nbsp;The group’s standards are high, consistent, and transparent, and their conclusions are influential on clinicians, payers, and the government for good reason: they are well informed and reliable.</p>\r\n
    <p>But they are not infallible.&nbsp;Applying very strict standards of evidence to the medical literature has a well-known liability attached to it: the potential conflation of absence of evidence with evidence of absence.&nbsp;The latter is when we know, decisively, that something does not work.&nbsp;The former- far more common, alas- is when the current state of evidence is insufficient to tell us for sure one way or the other.</p>\r\n
    <p>The&nbsp;Task Force&nbsp;is no stranger to the problem of absence of evidence.&nbsp;Many times over the years they have concluded, in effect, that they could not reach a conclusion.&nbsp;The customary language has been along the lines of: “evidence is insufficient to assess the balance of benefits and harms for…”&nbsp;A current example garnering just such guidance, and a letter grade of “I” to denote the insufficiency of evidence, is routine screening for&nbsp;<a href="https://www.uspreventiveservicestaskforce.org/Page/Document/UpdateSummaryFinal/cognitive-impairment-in-older-adults-screening" target="_blank" rel="nofollow noopener">cognitive impairment in older adults</a>.&nbsp;</p>\r\n
    <p>The&nbsp;Task Force&nbsp;is also able to acknowledge that at times there is sufficient evidence regarding benefits and harms, but that they are too closely balanced on the scales of public health to render a summary judgment.&nbsp;They have recently reached just such a conclusion regarding&nbsp;<a href="https://www.linkedin.com/pulse/prostate-screening-gets-personal-david?trk=mp-reader-card" target="_blank" rel="noopener">prostate cancer screening</a>, assigning&nbsp;<a href="https://www.uspreventiveservicestaskforce.org/Page/Name/grade-definitions" target="_blank" rel="nofollow noopener">a letter grade of “C.”</a></p>\r\n
    <p>Unfortunately, the latest draft recommendation issued by the&nbsp;Task Force- addressing the use of&nbsp;<a href="https://www.uspreventiveservicestaskforce.org/Announcements/News/Item/menopausal-hormone-therapy-for-the-primary-prevention-of-chronic-conditions" target="_blank" rel="nofollow noopener">hormone replacement at menopause to reduce the risk of chronic disease</a>- misconstrues absence of evidence for evidence of absence, and overlooks some crucial evidence into the bargain.&nbsp;The&nbsp;Task Force&nbsp;has rendered&nbsp;<a href="https://www.uspreventiveservicestaskforce.org/Page/Document/draft-recommendation-statement/menopausal-hormone-therapy-preventive-medication1" target="_blank" rel="nofollow noopener">a verdict of “D”</a>&nbsp;for that topic, inveighing against it.&nbsp;This is only a draft recommendation at this point, and we are in an open comment period.&nbsp;So here’s my comment: the&nbsp;Task Force&nbsp;got this one wrong.</p>\r\n
    <p>With the possible exception of nutrition, where we seem entirely committed to&nbsp;<a href="http://health.usnews.com/health-news/blogs/eat-run/articles/2016-01-19/dietary-pseudo-confusion-of-fire-and-rain" target="_blank" rel="nofollow noopener">perpetual confusion</a>&nbsp;despite&nbsp;<a href="http://www.truehealthinitiative.org/" target="_blank" rel="nofollow noopener">the clarity of fundamental truths</a>, few topics in medicine have been so badly muddled as hormone replacement (HR) at menopause.&nbsp;For many years, we were all quite confident in considerable, net benefits based on observational studies.&nbsp;During that era, we were surely mistaking some bathwater for the baby.</p>\r\n
    <p>Then, when randomized trials, notably HERS and the WHI, were conducted- a small surfeit of harms were seen with HR.&nbsp;Note that the surfeit was, indeed, small, and the results of both trials showed a mix of harms and benefits- with no difference between intervention and control groups in total mortality.&nbsp;Rather, the WHI was stopped early once it was clear that hormone replacement was&nbsp;<a href="http://jamanetwork.com/journals/jama/fullarticle/195120" target="_blank" rel="nofollow noopener">not on track to produce a statistically significant benefit overall</a>.</p>\r\n
    <p>How did a mix of benefits and harms, no overall mortality difference, and “not consistent with the requirements for a viable intervention for primary prevention of chronic diseases” get translated into a blanket recommendation against HR?&nbsp;By distorting the subtleties of the evidence into the customary and toxic brew that results routinely when medicine and the media cook together: hyperbole, oversimplification, and the banality of sound bites.&nbsp;</p>\r\n
    <p>The media in general are devoted less to our edification and more to our fleeting but recurrent attention, and titillation. The prevailing mantra is “afflict the comfortable, comfort the afflicted.”&nbsp;This has direct implications for HR at menopause that have&nbsp;<a href="https://www.ncbi.nlm.nih.gov/pubmed/18083455" target="_blank" rel="nofollow noopener">concerned me deeply for a decade</a>&nbsp;or more, and is a general threat to&nbsp;<a href="https://www.ncbi.nlm.nih.gov/pubmed/28523941" target="_blank" rel="nofollow noopener">understanding in the service of public health</a>.&nbsp;</p>\r\n
    <p>We had grown comfortable with the idea that HR reduced chronic disease risk, so a qualified reality check indicating that the matter was subject to considerable uncertainties was the truth, but a truth unsuitable for afflicting the comfortable.&nbsp;To afflict the comfortable, the media message needed to be: “hormone replacement will kill you now.”&nbsp;In 2002, there were many headlines along just such lines.</p>\r\n
    <p>That the benefits and harms were closely balanced was the least of the reasons this media 180 was egregious and harmful.&nbsp;Another, more important matter was that only one very particular, and notoriously bad version of HR had been studied: the combination of horse (rather than human) estrogen (Premarin), with a high-potency, synthetic progesterone (Provera).&nbsp;By way of analogy, we might conduct a study of breathing oxygen at some concentration markedly different from that in our native atmosphere, tally the harms of oxygen toxicity, and issue a blanket recommendation against breathing the stuff.&nbsp;If you don’t immediately see the folly in that, I invite you to hold your breath until it comes to you.</p>\r\n
    <p>But even the fact that there are different approaches to HR, and much better preparations than “Prem/Pro,” was not the biggest problem with the&nbsp;HR-is-bad-for-you-nowconclusion.&nbsp;The biggest problem was that: women vary.&nbsp;</p>\r\n
    <p>All of the data on HR and health outcomes, viewed with careful attention to sub-groups, show a highly significant, age-related pattern.&nbsp;Women who replace ovarian hormones right at menopause derive considerable benefit; women who delay for a decade do not.&nbsp;Summary judgment that ignores this highly significant dichotomy is seriously deficient.</p>\r\n
    <p>Also misguided is applying the questionable conclusion we have reached about combination HR (estrogen plus progesterone) to other forms of HR, namely estrogen alone.&nbsp;Women who have undergone hysterectomy- a population of some 20 million in the U.S.- can take estrogen on its own.&nbsp;The WHI study showed that the use of unopposed estrogen in women with prior hysterectomy who took it early after menopause reduced mortality significantly.&nbsp;Worded differently: the fear of HR induced by our “afflict the comfortable” approach to medical news&nbsp;<a href="https://www.ncbi.nlm.nih.gov/pubmed/23865654" target="_blank" rel="nofollow noopener">has killed tens of thousands of women prematurely, and needlessly</a>, over the past decade and a half.</p>\r\n
    <p>The wrong hormone replacement at the wrong time for the wrong women is sure to impose net harm.&nbsp;The right preparations at the right time for the right women are reliably beneficial.&nbsp;Much decision-making takes place between these obvious extremes, and such decisions should- like those for prostate cancer screening- issue from personal discussions between patient and provider.&nbsp;</p>\r\n
    <p>Summary judgment against HR is unfounded, misguided, and leads only to the perpetuation of a vintage mistake in new directions.&nbsp;I encourage the&nbsp;Task Force&nbsp;to reconsider this topic accordingly.&nbsp;In the interim, I advise a discussion with your provider about what’s right for you, to find a personalized path through the prevailing muddle.</p>
    """
  -user: Proxies\__CG__\App\Entity\User {#1092 …}
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  -updatedAt: DateTime @1526142669 {#1150
    date: 2018-05-12 16:31:09.0 UTC (+00:00)
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  -metakey: ""
  -metadesc: "By definition, a muddle is an untidy or disorganized collection.\u{A0}The verb denotes propagating confusion by bringing some topic into just such a state.\u{A0}I regret to say that, accordingly, the\u{A0}United States Preventive Services Task Force\u{A0}(USPSTF) is poised to muddle the management of symptoms, and chronic disease risk at menopause."
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AppController :: renderFooter (token = 781e27)

Key Value
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"App\Controller\AppController::renderFooter"
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"html"
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"8c7ddb"

CookieController :: renderCookie (token = 4c0fce)

Key Value
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"App\Controller\CookieController::renderCookie"
_format
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"60deb9"