GET https://rct.dev.bbntimes.com/science/dna-is-not-destiny-well-duh

Response
200 OK
IP
3.142.53.239
Profiled on
Token
de90bb

ArticleController :: show

Request

GET Parameters

None

POST Parameters

None

Uploaded Files

None

Request Attributes

Key Value
_controller 
"App\Controller\ArticleController::show"
_firewall_context 
"security.firewall.map.context.main"
_links 
Symfony\Component\WebLink\GenericLinkProvider {#3615
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    }
    3728 => Symfony\Component\WebLink\Link {#3728
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      -attributes: [
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    3723 => Symfony\Component\WebLink\Link {#3723
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"article_show"
_route_params 
[
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]
_security_firewall_run 
"_security_main"
_stopwatch_token 
"5fa519"
category 
"science"
slug 
"dna-is-not-destiny-well-duh"

Request Headers

Header Value
accept 
"*/*"
accept-encoding 
"gzip, br, zstd, deflate"
connection 
"close"
cookie 
"PHPSESSID=mkd46ju7nl7v9hg42068q8e581"
host 
"rct.dev.bbntimes.com"
user-agent 
"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)"
x-php-ob-level 
"1"

Request Content

Request content not available (it was retrieved as a resource).

Response

Response Headers

Header Value
cache-control 
"no-cache, private"
content-type 
"text/html; charset=UTF-8"
date 
"Wed, 16 Apr 2025 06:06:39 GMT"
link 
"</build/runtime.js>; rel="preload"; as="script",</build/644.js>; rel="preload"; as="script",</build/502.js>; rel="preload"; as="script",</build/app.js>; rel="preload"; as="script",</build/view-more.js>; rel="preload"; as="script",</build/term-condition.js>; rel="preload"; as="script",</build/contact.js>; rel="preload"; as="script",</build/scroll-infinite-article.js>; rel="preload"; as="script",</build/app.css>; rel="preload"; as="style",</build/cookie-style.css>; rel="preload"; as="style",</build/term-condition-css.css>; rel="preload"; as="style",</build/contact-css.css>; rel="preload"; as="style",</build/comment-css.css>; rel="preload"; as="style""
x-debug-token 
"de90bb"

Cookies

Request Cookies

Key Value
PHPSESSID 
"mkd46ju7nl7v9hg42068q8e581"

Response Cookies

No response cookies

Session 6

Session Metadata

Key Value
Created 
"Wed, 16 Apr 25 06:05:32 +0000"
Last used 
"Wed, 16 Apr 25 06:06:37 +0000"
Lifetime 
0

Session Attributes

Attribute Value
_csrf/https-comment 
"wtMFykbja_hxtaEnXc7TU7lHzRxn-0tLqZW9uFLALcI"
_csrf/https-cookie_accept 
"ciduMtJpLjUYO6QQ2bsjloEZvXcGXSrveLIZSDvKAkE"

Session Usage

6 Usages
Stateless check enabled
Usage
Symfony\Component\Security\Csrf\TokenStorage\SessionTokenStorage:76
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Symfony\Component\Security\Csrf\TokenStorage\SessionTokenStorage:79
Show trace 
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Symfony\Component\Security\Csrf\TokenStorage\SessionTokenStorage:52
Show trace 
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Symfony\Component\Security\Csrf\TokenStorage\SessionTokenStorage:56
Show trace 
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    "class" => "App\Controller\ArticleController"
    "type" => "->"
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    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpKernel.php"
    "line" => 76
    "function" => "handleRaw"
    "class" => "Symfony\Component\HttpKernel\HttpKernel"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/Kernel.php"
    "line" => 197
    "function" => "handle"
    "class" => "Symfony\Component\HttpKernel\HttpKernel"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/runtime/Runner/Symfony/HttpKernelRunner.php"
    "line" => 35
    "function" => "handle"
    "class" => "Symfony\Component\HttpKernel\Kernel"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/autoload_runtime.php"
    "line" => 29
    "function" => "run"
    "class" => "Symfony\Component\Runtime\Runner\Symfony\HttpKernelRunner"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/public/index.php"
    "line" => 5
    "args" => [
      "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/autoload_runtime.php"
    ]
    "function" => "require_once"
  ]
]
Symfony\Component\Security\Core\Authentication\Token\Storage\UsageTrackingTokenStorage:41
Show trace 
[
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/security-core/Authentication/Token/Storage/UsageTrackingTokenStorage.php"
    "line" => 41
    "function" => "getMetadataBag"
    "class" => "Symfony\Component\HttpFoundation\Session\Session"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/twig-bridge/AppVariable.php"
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    "function" => "getToken"
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    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/Extension/CoreExtension.php"
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    "function" => "twig_get_attribute"
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    "function" => "doDisplay"
    "class" => "__TwigTemplate_824a013e4f3f4a68e03a2d244e765025"
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    "function" => "displayWithErrorHandling"
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    "line" => 379
    "function" => "display"
    "class" => "Twig\Template"
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  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/TemplateWrapper.php"
    "line" => 38
    "function" => "render"
    "class" => "Twig\Template"
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  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/Environment.php"
    "line" => 280
    "function" => "render"
    "class" => "Twig\TemplateWrapper"
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  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/framework-bundle/Controller/AbstractController.php"
    "line" => 448
    "function" => "render"
    "class" => "Twig\Environment"
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  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/framework-bundle/Controller/AbstractController.php"
    "line" => 453
    "function" => "doRenderView"
    "class" => "Symfony\Bundle\FrameworkBundle\Controller\AbstractController"
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  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/framework-bundle/Controller/AbstractController.php"
    "line" => 253
    "function" => "doRender"
    "class" => "Symfony\Bundle\FrameworkBundle\Controller\AbstractController"
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  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/src/Controller/AppController.php"
    "line" => 126
    "function" => "render"
    "class" => "Symfony\Bundle\FrameworkBundle\Controller\AbstractController"
    "type" => "->"
  ]
  [
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    "line" => 181
    "function" => "renderHeader"
    "class" => "App\Controller\AppController"
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  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpKernel.php"
    "line" => 76
    "function" => "handleRaw"
    "class" => "Symfony\Component\HttpKernel\HttpKernel"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpCache/SubRequestHandler.php"
    "line" => 86
    "function" => "handle"
    "class" => "Symfony\Component\HttpKernel\HttpKernel"
    "type" => "->"
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  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/Fragment/InlineFragmentRenderer.php"
    "line" => 78
    "function" => "handle"
    "class" => "Symfony\Component\HttpKernel\HttpCache\SubRequestHandler"
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  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/Fragment/FragmentHandler.php"
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    "function" => "render"
    "class" => "Symfony\Component\HttpKernel\Fragment\InlineFragmentRenderer"
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    "function" => "render"
    "class" => "Symfony\Component\HttpKernel\Fragment\FragmentHandler"
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  [
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    "line" => 44
    "function" => "render"
    "class" => "Symfony\Component\HttpKernel\DependencyInjection\LazyLoadingFragmentHandler"
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  [
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  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/Template.php"
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    "function" => "block_header"
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  [
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    "function" => "displayBlock"
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    "function" => "displayWithErrorHandling"
    "class" => "Twig\Template"
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  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/var/cache/dev/twig/c3/c336f4e76fc20e4db84e3be131276b68.php"
    "line" => 52
    "function" => "display"
    "class" => "Twig\Template"
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  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/Template.php"
    "line" => 394
    "function" => "doDisplay"
    "class" => "__TwigTemplate_3ce0324a396de697d1fad9fabd68df72"
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  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/Template.php"
    "line" => 367
    "function" => "displayWithErrorHandling"
    "class" => "Twig\Template"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/Template.php"
    "line" => 379
    "function" => "display"
    "class" => "Twig\Template"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/TemplateWrapper.php"
    "line" => 38
    "function" => "render"
    "class" => "Twig\Template"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/twig/twig/src/Environment.php"
    "line" => 280
    "function" => "render"
    "class" => "Twig\TemplateWrapper"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/framework-bundle/Controller/AbstractController.php"
    "line" => 448
    "function" => "render"
    "class" => "Twig\Environment"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/framework-bundle/Controller/AbstractController.php"
    "line" => 453
    "function" => "doRenderView"
    "class" => "Symfony\Bundle\FrameworkBundle\Controller\AbstractController"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/framework-bundle/Controller/AbstractController.php"
    "line" => 253
    "function" => "doRender"
    "class" => "Symfony\Bundle\FrameworkBundle\Controller\AbstractController"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/src/Controller/ArticleController.php"
    "line" => 277
    "function" => "render"
    "class" => "Symfony\Bundle\FrameworkBundle\Controller\AbstractController"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpKernel.php"
    "line" => 181
    "function" => "show"
    "class" => "App\Controller\ArticleController"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpKernel.php"
    "line" => 76
    "function" => "handleRaw"
    "class" => "Symfony\Component\HttpKernel\HttpKernel"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/Kernel.php"
    "line" => 197
    "function" => "handle"
    "class" => "Symfony\Component\HttpKernel\HttpKernel"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/runtime/Runner/Symfony/HttpKernelRunner.php"
    "line" => 35
    "function" => "handle"
    "class" => "Symfony\Component\HttpKernel\Kernel"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/autoload_runtime.php"
    "line" => 29
    "function" => "run"
    "class" => "Symfony\Component\Runtime\Runner\Symfony\HttpKernelRunner"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/public/index.php"
    "line" => 5
    "args" => [
      "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/autoload_runtime.php"
    ]
    "function" => "require_once"
  ]
]
Symfony\Component\Security\Http\Firewall\ContextListener:171
Show trace 
[
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/security-http/Firewall/ContextListener.php"
    "line" => 171
    "function" => "remove"
    "class" => "Symfony\Component\HttpFoundation\Session\Session"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/event-dispatcher/Debug/WrappedListener.php"
    "line" => 116
    "function" => "onKernelResponse"
    "class" => "Symfony\Component\Security\Http\Firewall\ContextListener"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/event-dispatcher/EventDispatcher.php"
    "line" => 220
    "function" => "__invoke"
    "class" => "Symfony\Component\EventDispatcher\Debug\WrappedListener"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/event-dispatcher/EventDispatcher.php"
    "line" => 56
    "function" => "callListeners"
    "class" => "Symfony\Component\EventDispatcher\EventDispatcher"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/event-dispatcher/Debug/TraceableEventDispatcher.php"
    "line" => 139
    "function" => "dispatch"
    "class" => "Symfony\Component\EventDispatcher\EventDispatcher"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpKernel.php"
    "line" => 214
    "function" => "dispatch"
    "class" => "Symfony\Component\EventDispatcher\Debug\TraceableEventDispatcher"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpKernel.php"
    "line" => 202
    "function" => "filterResponse"
    "class" => "Symfony\Component\HttpKernel\HttpKernel"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpKernel.php"
    "line" => 76
    "function" => "handleRaw"
    "class" => "Symfony\Component\HttpKernel\HttpKernel"
    "type" => "->"
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  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/Kernel.php"
    "line" => 197
    "function" => "handle"
    "class" => "Symfony\Component\HttpKernel\HttpKernel"
    "type" => "->"
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  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/runtime/Runner/Symfony/HttpKernelRunner.php"
    "line" => 35
    "function" => "handle"
    "class" => "Symfony\Component\HttpKernel\Kernel"
    "type" => "->"
  ]
  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/autoload_runtime.php"
    "line" => 29
    "function" => "run"
    "class" => "Symfony\Component\Runtime\Runner\Symfony\HttpKernelRunner"
    "type" => "->"
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  [
    "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/public/index.php"
    "line" => 5
    "args" => [
      "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/autoload_runtime.php"
    ]
    "function" => "require_once"
  ]
]

Flashes

Flashes

No flash messages were created.

Server Parameters

Server Parameters

Defined in .env

Key Value
APP_ENV 
"dev"
APP_SECRET 
"0a988e63f011514eaabfc650b599af4d"
CORS_ALLOW_ORIGIN 
"*"
DATABASE_URL 
"mysql://bbndb_rctuser:33F5W25z40or0f7@localhost:3306/rct_bbntimes"
GOOGLE_RECAPTCHA_SECRET_KEY 
"6LdV5fgpAAAAANxzTG8ZMfIjil1wu-1vrQvnUt-x"
GOOGLE_RECAPTCHA_SITE_KEY 
"6LdV5fgpAAAAAENKcn73MJAhQrbtQeqgyC4wDLMP"
MAILER_DSN 
"smtp://no-reply%40rct.dev.bbntimes.com:Bl6%26gLD48%26Of919@rct.dev.bbntimes.com:465"
MARIADB_PASSWORD 
"i!87pK&!85ezc8"

Defined as regular env variables

Key Value
APP_DEBUG 
"1"
BASE 
"/public"
CONTEXT_DOCUMENT_ROOT 
"/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com"
CONTEXT_PREFIX 
""
DOCUMENT_ROOT 
"/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com"
FCGI_ROLE 
"RESPONDER"
GATEWAY_INTERFACE 
"CGI/1.1"
HTTPS 
"on"
HTTP_ACCEPT 
"*/*"
HTTP_ACCEPT_ENCODING 
"gzip, br, zstd, deflate"
HTTP_CONNECTION 
"close"
HTTP_COOKIE 
"PHPSESSID=mkd46ju7nl7v9hg42068q8e581"
HTTP_HOST 
"rct.dev.bbntimes.com"
HTTP_USER_AGENT 
"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)"
PASSENGER_COMPILE_NATIVE_SUPPORT_BINARY 
"0"
PASSENGER_DOWNLOAD_NATIVE_SUPPORT_BINARY 
"0"
PATH 
"/usr/local/sbin:/usr/local/bin:/usr/sbin:/usr/bin:/sbin:/bin:/snap/bin"
PHP_SELF 
"/public/index.php"
PP_CUSTOM_PHP_CGI_INDEX 
"plesk-php81-fastcgi"
PP_CUSTOM_PHP_INI 
"/var/www/vhosts/system/rct.dev.bbntimes.com/etc/php.ini"
QUERY_STRING 
""
REDIRECT_BASE 
"/public"
REDIRECT_HTTPS 
"on"
REDIRECT_PASSENGER_COMPILE_NATIVE_SUPPORT_BINARY 
"0"
REDIRECT_PASSENGER_DOWNLOAD_NATIVE_SUPPORT_BINARY 
"0"
REDIRECT_REDIRECT_HTTPS 
"on"
REDIRECT_REDIRECT_PASSENGER_COMPILE_NATIVE_SUPPORT_BINARY 
"0"
REDIRECT_REDIRECT_PASSENGER_DOWNLOAD_NATIVE_SUPPORT_BINARY 
"0"
REDIRECT_REDIRECT_SCRIPT_URI 
"https://rct.dev.bbntimes.com/science/dna-is-not-destiny-well-duh"
REDIRECT_REDIRECT_SCRIPT_URL 
"/science/dna-is-not-destiny-well-duh"
REDIRECT_REDIRECT_SSL_TLS_SNI 
"rct.dev.bbntimes.com"
REDIRECT_REDIRECT_STATUS 
"200"
REDIRECT_REDIRECT_UNIQUE_ID 
"Z_9I7kXLWdKvg9wvL0IpGQAAAFA"
REDIRECT_SCRIPT_URI 
"https://rct.dev.bbntimes.com/science/dna-is-not-destiny-well-duh"
REDIRECT_SCRIPT_URL 
"/science/dna-is-not-destiny-well-duh"
REDIRECT_SSL_TLS_SNI 
"rct.dev.bbntimes.com"
REDIRECT_STATUS 
"200"
REDIRECT_UNIQUE_ID 
"Z_9I7kXLWdKvg9wvL0IpGQAAAFA"
REDIRECT_URL 
"/public/science/dna-is-not-destiny-well-duh"
REMOTE_ADDR 
"3.142.53.239"
REMOTE_PORT 
"46625"
REQUEST_METHOD 
"GET"
REQUEST_SCHEME 
"https"
REQUEST_TIME 
1744783598
REQUEST_TIME_FLOAT 
1744783598.7049
REQUEST_URI 
"/science/dna-is-not-destiny-well-duh"
SCRIPT_FILENAME 
"/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/public/index.php"
SCRIPT_NAME 
"/public/index.php"
SCRIPT_URI 
"https://rct.dev.bbntimes.com/science/dna-is-not-destiny-well-duh"
SCRIPT_URL 
"/science/dna-is-not-destiny-well-duh"
SERVER_ADDR 
"5.196.1.209"
SERVER_ADMIN 
"[no address given]"
SERVER_NAME 
"rct.dev.bbntimes.com"
SERVER_PORT 
"443"
SERVER_PROTOCOL 
"HTTP/1.1"
SERVER_SIGNATURE 
"<address>Apache Server at rct.dev.bbntimes.com Port 443</address>\n"
SERVER_SOFTWARE 
"Apache"
SSL_TLS_SNI 
"rct.dev.bbntimes.com"
SYMFONY_DOTENV_VARS 
"APP_ENV,APP_SECRET,DATABASE_URL,MARIADB_PASSWORD,CORS_ALLOW_ORIGIN,MAILER_DSN,GOOGLE_RECAPTCHA_SECRET_KEY,GOOGLE_RECAPTCHA_SITE_KEY"
UNIQUE_ID 
"Z_9I7kXLWdKvg9wvL0IpGQAAAFA"

Sub Requests 6

CookieController :: renderAnalysis (token = 641933)

Key Value
_controller 
"App\Controller\CookieController::renderAnalysis"
_format 
"html"
_locale 
"en"
_stopwatch_token 
"3bd936"

AppController :: renderHeader (token = 4d91a8)

Key Value
_controller 
"App\Controller\AppController::renderHeader"
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"html"
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"en"
_stopwatch_token 
"a8c281"
slug 
"home"

ArticleController :: trendingArticle (token = 5956db)

Key Value
_controller 
"App\Controller\ArticleController::trendingArticle"
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"html"
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"en"
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"d0056f"
category 
"Science"

ArticleController :: relatedArticles (token = 1ba52f)

Key Value
_controller 
"App\Controller\ArticleController::relatedArticles"
_format 
"html"
_locale 
"en"
_stopwatch_token 
"59f4dd"
current_article 
App\Entity\Article {#1094
  -id: 3092
  -title: "DNA Is Not Destiny? Well, Duh"
  -slug: "dna-is-not-destiny-well-duh"
  -introtext: "<p>A&nbsp;<a href="http://www.nature.com/nature/journal/vaop/ncurrent/full/nature16166.html" target="_blank" rel="nofollow noopener">high profile paper</a>&nbsp;previously published in the highly prestigious journal,&nbsp;<em>Nature</em>, suggests that overwhelmingly, cancer results from “extrinsic factors,” namely behaviors and exposures, rather than the “intrinsic” transgressions of our chromosomes. The media response is a proclamation that no, cancer is not just about “<a href="http://www.latimes.com/science/sciencenow/la-sci-sn-cancer-more-than-just-bad-luck-20151215-story.html" target="_blank" rel="nofollow noopener">bad luck</a>.” So august a platform for so salient a proposition seems to demand a highly erudite response, and I’ve got just the one: duh.</p>\r\n"
  -content: """
    \r\n
    <p>Didn’t we know this already?</p>\r\n
    <p>Yes, it’s true, that almost exactly three years ago,&nbsp;<a href="http://www.sciencemag.org/content/347/6217/78" target="_blank" rel="nofollow noopener">a paper</a>&nbsp;was published in the only journal that competes with&nbsp;<em>Nature</em>&nbsp;for prestige,&nbsp;<em>Science</em>, attributing cancer risk to the frequency of stem cell divisions – and propagating a spate of media coverage about the&nbsp;<a href="http://www.nytimes.com/2015/01/06/health/cancers-random-assault.html" target="_blank" rel="nofollow noopener">randomness of cancer</a>. But the&nbsp;<a href="https://www.linkedin.com/pulse/cancer-random-genes-fortune-favors-prepared-david-l-katz-md-mph" target="_blank" rel="noopener">fallacy in that reporting</a>&nbsp;is a long-established fact of epidemiology:&nbsp;<a href="http://www.who.int/mediacentre/factsheets/fs297/en/" target="_blank" rel="nofollow noopener">cancer rates vary</a>&nbsp;substantially with lifestyle and environments. While variation in stem cell divisions might say something about the aggregation of mutations in any given tissue, we have long had cause to know it does not meaningfully account for&nbsp;<a href="https://www.linkedin.com/redir/general-malware-page?url=http%3A%2F%2Fnews%2ehealth%2ecom%2F2015%2F12%2F15%2Fcancer-rates-dropping-in-rich-countries-rising-in-poorer-ones-study%2F" target="_blank" rel="nofollow noopener">differential cancer risk among people, or populations</a>.</p>\r\n
    <p>The novelty of the new paper is not the emphasis on environmental and behavioral explanations for many cases of cancer. One might call that yesterday’s news, but in reality, it was yesterday’s news long before yesterday; it was yesterday’s news in 1982. Sir Richard Doll and Richard Peto published&nbsp;<a href="http://www.ncbi.nlm.nih.gov/pubmed/7017215" target="_blank" rel="nofollow noopener">a famous paper</a>&nbsp;in the&nbsp;<em>Journal of the National Cancer Institute</em>&nbsp;in 1981, characterizing the substantial preventability of cancer. A&nbsp;<a href="http://www.ncbi.nlm.nih.gov/pubmed/25739419" target="_blank" rel="nofollow noopener">reassessment</a>&nbsp;of their estimates concluded they appear to be valid after 35 years of scrutiny. And, of course, when McGinnis and Foege&nbsp;<a href="http://www.ncbi.nlm.nih.gov/pubmed/8411605" target="_blank" rel="nofollow noopener">told us in 1993</a>&nbsp;that premature deaths in the United States were overwhelmingly preventable, again by modifying behaviors and exposures, cancer deaths were certainly in that mix.</p>\r\n
    <p>The novelty in the paper in&nbsp;<em>Nature</em>&nbsp;was to apply what we have long known about the salience of “extrinsic” causes of cancer directly to the proposition about “intrinsic” causes in the prior&nbsp;<em>Science</em>&nbsp;paper.&nbsp; What the current group concluded is that more frequent stem cell division does, indeed, create more opportunity for carcinogenic mutations - but that external factors provoke those mutations.&nbsp;<em>Nature</em>, in other words, has come down on the side of nurture.</p>\r\n
    <p>In this epigenetic age, there is an expression that captures this interplay:&nbsp;<em><a href="http://www.brainyquote.com/quotes/quotes/m/mehmetoz433794.html" target="_blank" rel="nofollow noopener">genes load the gun, but lifestyle pulls the trigger</a></em>.</p>\r\n
    <p>Even more bluntly: DNA is not destiny. There are exceptions, of course. If you are dealt two copies of the sickle cell anemia gene, you develop sickle cell anemia inevitably. The same is true with just one copy of the gene for&nbsp;<a href="http://www.ncbi.nlm.nih.gov/pubmedhealth/PMHT0024706/" target="_blank" rel="nofollow noopener">Huntington’s Disease</a>. Such exceptions are rare enough, however, to reaffirm rather than refute the basic proposition: generally, DNA is not destiny.</p>\r\n
    <p>To a large, and largely neglected degree - dinner is. Or could be.</p>\r\n
    <p>Of course, the alliteration is nice - but it’s not really just “dinner.” It’s breakfast, too. It's our overall dietary pattern. And it’s not just diet either. It’s our&nbsp;<a href="http://www.lifestylemedicine.org/" target="_blank" rel="nofollow noopener">lifestyle</a>.</p>\r\n
    <p>Lifestyle, in turn, is accountable to and dependent on social and environmental factors. Even causes have causes. The choices we make are ultimately subordinate to the choices we have. Some whole cultures serve up choices that foster health. Some do&nbsp;<a href="http://health.usnews.com/health-news/blogs/eat-run/2012/10/04/is-obesity-cultural" target="_blank" rel="nofollow noopener">rather the contrary</a>.</p>\r\n
    <p>Still, we might constructively collate these insights. Whether by virtue of behaviors chosen and practiced by individual bodies, or by exposures, environments, and policies referable to the body politic - the underlying causes of cancer, as for other major chronic diseases, are&nbsp;<a href="http://www.ncbi.nlm.nih.gov/pubmed/19667296" target="_blank" rel="nofollow noopener">overwhelmingly preventable</a>. The paper posits the arrestingly high figure of&nbsp;<a href="http://www.latimes.com/science/sciencenow/la-sci-sn-cancer-more-than-just-bad-luck-20151215-story.html" target="_blank" rel="nofollow noopener">up to 90%</a>&nbsp;so. Whether it is that, or the&nbsp;<a href="http://www.cbsnews.com/news/two-thirds-of-cancer-cases-preventable-study-finds/" target="_blank" rel="nofollow noopener">more modest 60%</a>&nbsp;that has long been touted by those in the know - it is a luminous and tantalizing proposition just the same.</p>\r\n
    <p>Even as we concede that the daily choices we make as individuals are to varying degrees subordinate to the choices we have by virtue of our culture, we might acknowledge one choice we could make any time. We could choose to stop rediscovering what we already know.</p>\r\n
    <p>We have long known that lifestyle practices - whether born of personal choice, or public action - could eliminate the majority of cancers, and an even higher majority of other chronic diseases. We have long known how to prevent some&nbsp;<a href="https://www.linkedin.com/pulse/20131124153502-23027997-lifestyle-as-medicine-at-a-fork-in-the-road-who-s-got-a-spoon?trk=mp-reader-card" target="_blank" rel="noopener">80% of premature deaths</a>.</p>\r\n
    <p>But as long as we remain interested in rediscovering what we know rather than putting it to good use, knowledge isn’t power. And while DNA isn’t destiny, at present, neither is dinner- at least not the favorable destiny it might be. Rather, our destiny seems much consigned to our collective,&nbsp;<a href="http://www.huffingtonpost.com/david-katz-md/the-obesity-fix_b_6261440.html" target="_blank" rel="nofollow noopener">cultural dysfunction</a>.</p>\r\n
    <p>We are ill served by headlines that made cancer random a year ago, and overwhelmingly preventable this year. Both studies in both prestigious journals contributed something to our basic understanding, but neither changed our options or the prevailing view from altitude. We don’t know how to prevent every case of cancer, certainly, but cancer- along with every other major chronic disease- occurs far less often in populations that eat well, don’t smoke, and stay active. The numerous centenarians in the&nbsp;<a href="https://www.bluezones.com/" target="_blank" rel="nofollow noopener">Blue Zones</a>&nbsp;are obviously not just not dying of heart attacks at age 70 or 80. Living to 100 means they are also not dying of anything else then either, cancer included.</p>\r\n
    <p>A New Year dawns, and with it, the alluring promise of knowledge. We may hope that some of that knowledge will pertain to advances in the prevention and effective treatment of cancers, particularly those that defy our best efforts, and those that do seem&nbsp;<a href="https://www.linkedin.com/pulse/rare-disease-indifference-righteous-indignation-l-katz-md-mph?trk=mp-reader-card" target="_blank" rel="noopener">truly random</a>. But perhaps one of its greatest prospects for us all resides with the opportunity to renounce the need to rediscover next year what we knew and failed to apply last.</p>\r\n
    <p>May this, then, be the year the wishful proposition about knowledge and power comes true. May it be the year we come together to lay hold of the&nbsp;<a href="https://www.linkedin.com/pulse/20131110133420-23027997-what-really-kills-us" target="_blank" rel="noopener">master levers of medical destiny</a>&nbsp;that have long been in our hands, and heave together. May this be the year we stop rediscovering what we already know, and actually, finally -&nbsp;<a href="http://www.truehealthinitiative.org/" target="_blank" rel="nofollow noopener">do something with it</a>.</p>
    """
  -user: Proxies\__CG__\App\Entity\User {#1092 …}
  -createdAt: DateTime @1543177199 {#1145
    date: 2018-11-25 20:19:59.0 UTC (+00:00)
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  -updatedAt: DateTime @1628454503 {#1150
    date: 2021-08-08 20:28:23.0 UTC (+00:00)
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  -status: "published"
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  -clicks: 5568
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  -reviewed_at: DateTime @1543177196 {#1148
    date: 2018-11-25 20:19:56.0 UTC (+00:00)
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  -metakey: ""
  -metadesc: "A\u{A0}high profile paper\u{A0}previously published in the highly prestigious journal,\u{A0}Nature, suggests that overwhelmingly, cancer results from “extrinsic factors,” namely behaviors and exposures, rather than the “intrinsic” transgressions of our chromosomes. The media response is a proclamation that no, cancer is not just about “bad luck.” So august a platform for so salient a proposition seems to demand a highly erudite response, and I’ve got just the one: duh."
  -robots: null
  -publishedAt: DateTime @1543177196 {#1147
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AppController :: renderFooter (token = 8720d7)

Key Value
_controller 
"App\Controller\AppController::renderFooter"
_format 
"html"
_locale 
"en"
_stopwatch_token 
"7dbcae"

CookieController :: renderCookie (token = 99797d)

Key Value
_controller 
"App\Controller\CookieController::renderCookie"
_format 
"html"
_locale 
"en"
_stopwatch_token 
"811e5c"