ArticleController :: show
Request
GET Parameters
None
POST Parameters
None
Uploaded Files
None
Request Attributes
Key | Value |
---|---|
_controller | "App\Controller\ArticleController::show" |
_firewall_context | "security.firewall.map.context.main" |
_links | Symfony\Component\WebLink\GenericLinkProvider {#3616 -links: [ 3737 => Symfony\Component\WebLink\Link {#3737 -href: "/build/runtime.js" -rel: [ "preload" => "preload" ] -attributes: [ "as" => "script" ] } 3735 => Symfony\Component\WebLink\Link {#3735 -href: "/build/644.js" -rel: [ "preload" => "preload" ] -attributes: [ "as" => "script" ] } 3734 => Symfony\Component\WebLink\Link {#3734 -href: "/build/502.js" -rel: [ "preload" => "preload" ] -attributes: [ "as" => "script" ] } 3733 => Symfony\Component\WebLink\Link {#3733 -href: "/build/app.js" -rel: [ "preload" => "preload" ] -attributes: [ "as" => "script" ] } 3732 => Symfony\Component\WebLink\Link {#3732 -href: "/build/view-more.js" -rel: [ "preload" => "preload" ] -attributes: [ "as" => "script" ] } 3731 => Symfony\Component\WebLink\Link {#3731 -href: "/build/term-condition.js" -rel: [ "preload" => "preload" ] -attributes: [ "as" => "script" ] } 3730 => Symfony\Component\WebLink\Link {#3730 -href: "/build/contact.js" -rel: [ "preload" => "preload" ] -attributes: [ "as" => "script" ] } 3729 => Symfony\Component\WebLink\Link {#3729 -href: "/build/scroll-infinite-article.js" -rel: [ "preload" => "preload" ] -attributes: [ "as" => "script" ] } 3728 => Symfony\Component\WebLink\Link {#3728 -href: "/build/app.css" -rel: [ "preload" => "preload" ] -attributes: [ "as" => "style" ] } 3727 => Symfony\Component\WebLink\Link {#3727 -href: "/build/cookie-style.css" -rel: [ "preload" => "preload" ] -attributes: [ "as" => "style" ] } 3726 => Symfony\Component\WebLink\Link {#3726 -href: "/build/term-condition-css.css" -rel: [ "preload" => "preload" ] -attributes: [ "as" => "style" ] } 3725 => Symfony\Component\WebLink\Link {#3725 -href: "/build/contact-css.css" -rel: [ "preload" => "preload" ] -attributes: [ "as" => "style" ] } 3724 => Symfony\Component\WebLink\Link {#3724 -href: "/build/comment-css.css" -rel: [ "preload" => "preload" ] -attributes: [ "as" => "style" ] } ] } |
_route | "article_show" |
_route_params | [ "category" => "science" "slug" => "the-importance-of-digital-health-package-inserts" ] |
_security_firewall_run | "_security_main" |
_stopwatch_token | "56f39f" |
category | "science" |
slug | "the-importance-of-digital-health-package-inserts" |
Request Headers
Header | Value |
---|---|
accept | "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" |
accept-encoding | "gzip, deflate, br, zstd" |
cache-control | "no-cache" |
connection | "close" |
host | "rct.dev.bbntimes.com" |
pragma | "no-cache" |
sec-ch-ua | ""Chromium";v="130", "HeadlessChrome";v="130", "Not?A_Brand";v="99"" |
sec-ch-ua-mobile | "?0" |
sec-ch-ua-platform | ""Windows"" |
sec-fetch-dest | "document" |
sec-fetch-mode | "navigate" |
sec-fetch-site | "none" |
sec-fetch-user | "?1" |
upgrade-insecure-requests | "1" |
user-agent | "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" |
x-php-ob-level | "1" |
Request Content
Request content not available (it was retrieved as a resource).
Response
Response Headers
Header | Value |
---|---|
cache-control | "no-cache, private" |
content-type | "text/html; charset=UTF-8" |
date | "Mon, 04 Aug 2025 21:51:35 GMT" |
link | "</build/runtime.js>; rel="preload"; as="script",</build/644.js>; rel="preload"; as="script",</build/502.js>; rel="preload"; as="script",</build/app.js>; rel="preload"; as="script",</build/view-more.js>; rel="preload"; as="script",</build/term-condition.js>; rel="preload"; as="script",</build/contact.js>; rel="preload"; as="script",</build/scroll-infinite-article.js>; rel="preload"; as="script",</build/app.css>; rel="preload"; as="style",</build/cookie-style.css>; rel="preload"; as="style",</build/term-condition-css.css>; rel="preload"; as="style",</build/contact-css.css>; rel="preload"; as="style",</build/comment-css.css>; rel="preload"; as="style"" |
x-debug-token | "ed543b" |
Cookies
Request Cookies
No request cookies
Response Cookies
No response cookies
Session 11
Session Metadata
Key | Value |
---|---|
Created | "Mon, 04 Aug 25 21:51:34 +0000" |
Last used | "Mon, 04 Aug 25 21:51:34 +0000" |
Lifetime | 0 |
Session Attributes
Attribute | Value |
---|---|
_csrf/https-comment | "XSieeKFHLNO667Ipk34fFVyVTG5FyIVfYP7W4kcZ4Gc" |
_csrf/https-cookie_accept | "yDno0-SkclYUMZYHBIBo72Z_fhXeOgnQbb7lwMyDMns" |
Session Usage
11
Usages
Stateless check enabled
Usage |
---|
Symfony\Component\Security\Csrf\TokenStorage\SessionTokenStorage:76
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Symfony\Component\Security\Csrf\TokenStorage\SessionTokenStorage:79
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Symfony\Component\Security\Csrf\TokenStorage\SessionTokenStorage:69
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Symfony\Component\Security\Csrf\TokenStorage\SessionTokenStorage:52
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Symfony\Component\Security\Csrf\TokenStorage\SessionTokenStorage:56
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Symfony\Component\HttpKernel\DataCollector\RequestDataCollector:69
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Symfony\Component\HttpKernel\DataCollector\RequestDataCollector:70
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Symfony\Component\HttpKernel\DataCollector\RequestDataCollector:71
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Symfony\Component\HttpKernel\DataCollector\RequestDataCollector:72
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Symfony\Component\HttpKernel\DataCollector\RequestDataCollector:73
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Symfony\Component\Security\Core\Authentication\Token\Storage\UsageTrackingTokenStorage:41
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"/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/src/Controller/ArticleController.php" "line" => 277 "function" => "render" "class" => "Symfony\Bundle\FrameworkBundle\Controller\AbstractController" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpKernel.php" "line" => 181 "function" => "show" "class" => "App\Controller\ArticleController" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/HttpKernel.php" "line" => 76 "function" => "handleRaw" "class" => "Symfony\Component\HttpKernel\HttpKernel" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/http-kernel/Kernel.php" "line" => 197 "function" => "handle" "class" => "Symfony\Component\HttpKernel\HttpKernel" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/symfony/runtime/Runner/Symfony/HttpKernelRunner.php" "line" => 35 "function" => "handle" "class" => "Symfony\Component\HttpKernel\Kernel" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/autoload_runtime.php" "line" => 29 "function" => "run" "class" => "Symfony\Component\Runtime\Runner\Symfony\HttpKernelRunner" "type" => "->" ] [ "file" => "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/public/index.php" "line" => 5 "args" => [ "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com/vendor/autoload_runtime.php" ] "function" => "require_once" ] ] |
Flashes
Flashes
No flash messages were created.
Server Parameters
Server Parameters
Defined in .env
Key | Value |
---|---|
APP_ENV | "dev" |
APP_SECRET | "0a988e63f011514eaabfc650b599af4d" |
CORS_ALLOW_ORIGIN | "*" |
DATABASE_URL | "mysql://bbndb_rctuser:33F5W25z40or0f7@localhost:3306/rct_bbntimes" |
GOOGLE_RECAPTCHA_SECRET_KEY | "6LdV5fgpAAAAANxzTG8ZMfIjil1wu-1vrQvnUt-x" |
GOOGLE_RECAPTCHA_SITE_KEY | "6LdV5fgpAAAAAENKcn73MJAhQrbtQeqgyC4wDLMP" |
MAILER_DSN | "smtp://no-reply%40rct.dev.bbntimes.com:Bl6%26gLD48%26Of919@rct.dev.bbntimes.com:465" |
MARIADB_PASSWORD | "i!87pK&!85ezc8" |
Defined as regular env variables
Key | Value |
---|---|
APP_DEBUG | "1" |
BASE | "/public" |
CONTEXT_DOCUMENT_ROOT | "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com" |
CONTEXT_PREFIX | "" |
DOCUMENT_ROOT | "/var/www/vhosts/dev.bbntimes.com/rct.dev.bbntimes.com" |
FCGI_ROLE | "RESPONDER" |
GATEWAY_INTERFACE | "CGI/1.1" |
HTTPS | "on" |
HTTP_ACCEPT | "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" |
HTTP_ACCEPT_ENCODING | "gzip, deflate, br, zstd" |
HTTP_CACHE_CONTROL | "no-cache" |
HTTP_CONNECTION | "close" |
HTTP_HOST | "rct.dev.bbntimes.com" |
HTTP_PRAGMA | "no-cache" |
HTTP_SEC_CH_UA | ""Chromium";v="130", "HeadlessChrome";v="130", "Not?A_Brand";v="99"" |
HTTP_SEC_CH_UA_MOBILE | "?0" |
HTTP_SEC_CH_UA_PLATFORM | ""Windows"" |
HTTP_SEC_FETCH_DEST | "document" |
HTTP_SEC_FETCH_MODE | "navigate" |
HTTP_SEC_FETCH_SITE | "none" |
HTTP_SEC_FETCH_USER | "?1" |
HTTP_UPGRADE_INSECURE_REQUESTS | "1" |
HTTP_USER_AGENT | "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" |
PASSENGER_COMPILE_NATIVE_SUPPORT_BINARY | "0" |
PASSENGER_DOWNLOAD_NATIVE_SUPPORT_BINARY | "0" |
PATH | "/usr/local/sbin:/usr/local/bin:/usr/sbin:/usr/bin:/sbin:/bin:/snap/bin" |
PHP_SELF | "/public/index.php" |
PP_CUSTOM_PHP_CGI_INDEX | "plesk-php81-fastcgi" |
PP_CUSTOM_PHP_INI | "/var/www/vhosts/system/rct.dev.bbntimes.com/etc/php.ini" |
QUERY_STRING | "" |
REDIRECT_BASE | "/public" |
REDIRECT_HTTPS | "on" |
REDIRECT_PASSENGER_COMPILE_NATIVE_SUPPORT_BINARY | "0" |
REDIRECT_PASSENGER_DOWNLOAD_NATIVE_SUPPORT_BINARY | "0" |
REDIRECT_REDIRECT_HTTPS | "on" |
REDIRECT_REDIRECT_PASSENGER_COMPILE_NATIVE_SUPPORT_BINARY | "0" |
REDIRECT_REDIRECT_PASSENGER_DOWNLOAD_NATIVE_SUPPORT_BINARY | "0" |
REDIRECT_REDIRECT_SCRIPT_URI | "https://rct.dev.bbntimes.com/science/the-importance-of-digital-health-package-inserts" |
REDIRECT_REDIRECT_SCRIPT_URL | "/science/the-importance-of-digital-health-package-inserts" |
REDIRECT_REDIRECT_SSL_TLS_SNI | "rct.dev.bbntimes.com" |
REDIRECT_REDIRECT_STATUS | "200" |
REDIRECT_REDIRECT_UNIQUE_ID | "aJErZQ3foZr7J-xQYIkhBwAAAEM" |
REDIRECT_SCRIPT_URI | "https://rct.dev.bbntimes.com/science/the-importance-of-digital-health-package-inserts" |
REDIRECT_SCRIPT_URL | "/science/the-importance-of-digital-health-package-inserts" |
REDIRECT_SSL_TLS_SNI | "rct.dev.bbntimes.com" |
REDIRECT_STATUS | "200" |
REDIRECT_UNIQUE_ID | "aJErZQ3foZr7J-xQYIkhBwAAAEM" |
REDIRECT_URL | "/public/science/the-importance-of-digital-health-package-inserts" |
REMOTE_ADDR | "216.73.216.137" |
REMOTE_PORT | "39397" |
REQUEST_METHOD | "GET" |
REQUEST_SCHEME | "https" |
REQUEST_TIME | 1754344293 |
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current_article | App\Entity\Article {#1094 -id: 4999 -title: "The Importance of Digital Health Package Inserts" -slug: "the-importance-of-digital-health-package-inserts" -introtext: "<p><a href="https://en.wikipedia.org/wiki/Medication_package_insert" target="_blank" rel="noopener">Package insert</a> is a document included in the <a href="https://en.wikipedia.org/wiki/Drug_packaging" target="_blank" rel="nofollow noopener">package</a> of a <a href="https://en.wikipedia.org/wiki/Medication" target="_blank" rel="nofollow noopener">medication</a> that provides information about that drug and its use. For <a href="https://en.wikipedia.org/wiki/Prescription_medication" target="_blank" rel="nofollow noopener">prescription medications</a>, the insert is <a href="https://en.wikipedia.org/wiki/Technical_writing" target="_blank" rel="nofollow noopener">technical</a>, and provides information for <a href="https://en.wikipedia.org/wiki/Health_professional" target="_blank" rel="nofollow noopener">medical professionals</a> about how to prescribe the drug. Package inserts for prescription drugs often include a separate document called a "patient package insert" with information written in <a href="https://en.wikipedia.org/wiki/Plain_English" target="_blank" rel="nofollow noopener">plain language</a> intended for the <a href="https://en.wikipedia.org/wiki/End-user" target="_blank" rel="nofollow noopener">end-user</a> -- the person who will take the drug or give the drug to another person, for example a minor. Inserts for <a href="https://en.wikipedia.org/wiki/Over-the-counter_medication" target="_blank" rel="nofollow noopener">over-the-counter medications</a> are also written plainly.</p>\r\n" -content: """ \r\n <p>In the US the document is called "prescribing information" or the "package insert" (PI) and layperson's document is called the patient package insert (PPI). In Europe the technical document is called the "<strong>summary of product characteristics</strong>" (SmPC) and the document for end-users is called the "<strong>patient information leaflet</strong>" (PIL) or "package leaflet".</p>\r\n <p>Given the confusion about 1)which digital health product to prescribe for any given patient, 2) the fact that many products are actually consumer products designated to provide information and education, not diagnosis or treatment, and 3) most are not clinically validated or cost-effective, perhaps its time to require package inserts for the prescriber and the patients.</p>\r\n <p>What is in a package insert is <a href="https://www.fda.gov/media/72979/download" target="_blank" rel="nofollow noopener">described and required by the FDA</a> and includes:</p>\r\n <ul>\r\n <li><a href="https://en.wikipedia.org/wiki/Clinical_pharmacology" target="_blank" rel="nofollow noopener">Clinical pharmacology</a> - tells how the medicine works in the body, how it is absorbed and eliminated, and what its effects are likely to be at various concentrations. May also contain results of various <a href="https://en.wikipedia.org/wiki/Clinical_trial" target="_blank" rel="nofollow noopener">clinical trials</a> (studies) and/or explanations of the medication's effect on various populations (e.g. children, women, etc.).<br /><br /></li>\r\n <li>Indications and usage - uses (indications) for which the drug has been FDA-approved (e.g. migraines, seizures, high blood pressure). Physicians legally can and often do prescribe medicines for purposes not listed in this section (so-called "<a href="https://en.wikipedia.org/wiki/Off-label_use" target="_blank" rel="nofollow noopener">off-label uses</a>").<br /><br /></li>\r\n <li><a href="https://en.wikipedia.org/wiki/Contraindications" target="_blank" rel="nofollow noopener">Contraindications</a> - lists situations in which the medication should <em>not</em> be used, for example in patients with other medical conditions such as kidney problems or allergies.<br /><br /></li>\r\n <li>Warnings - covers possible serious <a href="https://en.wikipedia.org/wiki/Adverse_drug_reaction" target="_blank" rel="nofollow noopener">side effects</a> that may occur.<br /><br /></li>\r\n <li>Precautions - explains how to use the medication safely including physical impairments and drug interactions; for example "Do not drink alcohol while taking this medication" or "Do not take this medication if you are currently taking <a href="https://en.wikipedia.org/wiki/Monoamine_oxidase_inhibitor" target="_blank" rel="nofollow noopener">MAOI inhibitors</a>".<br /><br /></li>\r\n <li>Adverse reactions - lists <em>all</em> side effects observed in all studies of the drug (as opposed to just the dangerous side effects which are separately listed in "Warnings" section).<br /><br /></li>\r\n <li>Drug abuse and dependence - provides information regarding whether prolonged use of the medication can cause <a href="https://en.wikipedia.org/wiki/Physical_dependence" target="_blank" rel="nofollow noopener">physical dependence</a> (only included if applicable).<br /><br /></li>\r\n <li>Overdosage - gives the results of an <a href="https://en.wikipedia.org/wiki/Overdose" target="_blank" rel="nofollow noopener">overdose</a> and provides recommended action in such cases.<br /><br /></li>\r\n <li>Dosage and administration - gives recommended dosage(s); may list more than one for different conditions or different patients (e.g., lower dosages for children).<br /><br /></li>\r\n <li>How supplied - explains in detail the physical characteristics of the medication including color, shape, markings, etc., and storage information (e.g., "Store between 68 and 78°F ").</li>\r\n </ul>\r\n <p>Of course, there would need to be some modifications, like:</p>\r\n <ol>\r\n <li>Safety and efficacy</li>\r\n <li>Cybersecurity risks</li>\r\n <li>Data security</li>\r\n <li><a href="https://knowledge.wharton.upenn.edu/article/data-shared-sold-whats-done/?utm_source=kw_newsletter&utm_medium=email&utm_campaign=2019-10-29" target="_blank" rel="nofollow noopener">Data , privacy, ownership and transfer rights</a></li>\r\n <li>Side effects</li>\r\n <li>Designation as a consumer product or a diagnostic or <a href="https://www.dtxalliance.org/" target="_blank" rel="nofollow noopener">therapeutic device</a></li>\r\n <li>Generic substitution possibilities</li>\r\n <li>Adverse app reactions</li>\r\n <li>App-app interactions</li>\r\n <li>Compatibility with other drugs or devices</li>\r\n </ol>\r\n <p>One thing that will not be in the insert will be what all this costs to you or someone else who has to pay for it.</p>\r\n <p>At this point you are probably thinking, "We have enough regulations and we love our APPs. So what if they don't make us any better." Go shove your insert. Next you'll be telling us it has to have all that cotton in the bottle too.</p>\r\n <p>Arlen Meyers, MD, MBA is the President and CEO of the <a href="http://www.sopenet.org/" target="_blank" rel="nofollow noopener">Society of Physician Entrepreneurs </a>on <a href="mailto:Twitter@ArlenMD and">Twitter@ArlenMD and</a> Co-editor of <a href="https://www.springer.com/gp/book/9783030127183" target="_blank" rel="nofollow noopener">Digital Health Entrepreneurship</a>.</p> """ -user: Proxies\__CG__\App\Entity\User {#1092 …} -createdAt: DateTime @1572468050 {#1145 : 2019-10-30 20:40:50.0 UTC (+00:00) } -updatedAt: DateTime @1572469504 {#1150 : 2019-10-30 21:05:04.0 UTC (+00:00) } -deletedAt: null -category: App\Entity\Category {#445 …} -status: "published" -imageCard: Proxies\__CG__\App\Entity\File {#1184 …} -ImageHeader: Proxies\__CG__\App\Entity\File {#1184 …} -featured: false -mainView: false -clicks: 6680 -comments: Doctrine\ORM\PersistentCollection {#1125 …} -reviewed_at: DateTime @1572468040 {#1148 : 2019-10-30 20:40:40.0 UTC (+00:00) } -metakey: "" -metadesc: "Package insert\u{A0}is a document included in the\u{A0}package\u{A0}of a\u{A0}medication\u{A0}that provides information about that drug and its use. For\u{A0}prescription medications, the insert is\u{A0}technical, and provides information for\u{A0}medical professionals\u{A0}about how to prescribe the drug. Package inserts for prescription drugs often include a separate document called a "patient package insert" with information written in\u{A0}plain language\u{A0}intended for the\u{A0}end-user\u{A0}-- the person who will take the drug or give the drug to another person, for example a minor. Inserts for\u{A0}over-the-counter medications\u{A0}are also written plainly." -robots: null -publishedAt: DateTime @1572468040 {#1147 : 2019-10-30 20:40:40.0 UTC (+00:00) } -canonical: null -superTag: null } |
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